Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Department of Clinical Neurophysiology, OLVG, Amsterdam, The Netherlands.
Sleep Breath. 2023 Oct;27(5):1857-1864. doi: 10.1007/s11325-023-02799-z. Epub 2023 Mar 3.
This study aimed to investigate the effects of continuous positive airway pressure (CPAP) and mandibular advancement appliance (MAA) therapy on rhythmic masticatory muscle activity (RMMA), a biomarker of sleep bruxism (SB), and to compare the effects of CPAP with MAA in adults with obstructive sleep apnea (OSA).
This cohort study included individuals with OSA who received treatment with CPAP or MAA. Polysomnographic recordings with and without therapy were performed in each individual. Statistical analyses were performed with repeated measures ANOVA.
A total of 38 individuals with OSA were enrolled, 13 on CPAP and 25 with MAA, mean age 52.6 ± 10.6 years, 32 men, mean baseline apnea-hypopnea index (AHI) 26.5 ± 15.2 events/hour, mean RMMA index 3.5 ±events/hour. In the total group, the RMMA index decreased significantly with CPAP and MAA therapies (P < 0.05). The changes in the RMMA index with therapy did not differ significantly between CPAP and MAA (P > 0.05). The RMMA index decreased in 60% of the individuals with OSA, and the changes ranged widely, with a median of 52% and an interquartile range of 107%.
Both CPAP and MAA therapies significantly reduce SB in individuals with OSA. However, the interindividual differences in the effects of these therapies on SB are large.
https://trialsearch.who.int (NL8516); April 08, 2020.
本研究旨在探讨持续气道正压通气（CPAP）和下颌前伸装置（MAA）治疗对睡眠磨牙症（SB）生物标志物——节律性咀嚼肌活动（RMMA）的影响，并比较 CPAP 和 MAA 治疗对阻塞性睡眠呼吸暂停（OSA）成人的疗效。
这项队列研究纳入了接受 CPAP 或 MAA 治疗的 OSA 患者。每位患者均进行了有治疗和无治疗的多导睡眠图记录。采用重复测量方差分析进行统计分析。
共纳入 38 例 OSA 患者，13 例接受 CPAP 治疗，25 例接受 MAA 治疗，平均年龄 52.6±10.6 岁，32 例男性，平均基线呼吸暂停低通气指数（AHI）为 26.5±15.2 事件/小时，平均 RMMA 指数为 3.5±事件/小时。在总组中，RMMA 指数随 CPAP 和 MAA 治疗显著降低（P<0.05）。CPAP 和 MAA 治疗对 RMMA 指数的改变无显著差异（P>0.05）。60%的 OSA 患者 RMMA 指数下降，变化范围广泛，中位数为 52%，四分位距为 107%。
CPAP 和 MAA 治疗均可显著降低 OSA 患者的 SB 发生率。然而，这些治疗对 SB 的个体疗效差异较大。
https://trialsearch.who.int（NL8516）；2020 年 4 月 8 日。
