School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, 2055 Yanan Street, Changchun, Jilin 130012, PR China.
State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, PR China.
J Photochem Photobiol B. 2023 Apr;241:112674. doi: 10.1016/j.jphotobiol.2023.112674. Epub 2023 Feb 24.
Antimicrobial photodynamic therapy (aPDT) is an effective strategy to eliminate bacteria without inducing bacterial resistance. As typical aPDT photosensitizers, most of boron-dipyrromethene (BODIPY) are hydrophobic, and nanometerization is imperative to render them dispersible in physiological media. Recently, carrier-free nanoparticles (NPs) are formed via the self-assembly of BODIPYs without the help of any surfactants or auxiliaries, arousing people's interest. So as to fabricate carrier-free NPs, BODIPYs usually need to be derived into dimers, trimers, or amphiphiles through complex reactions. Few unadulterated NPs were obtained from BODIPYs with precise structures. Herein, BNP1-BNP3 were synthesized by the self-assembly of BODIPY, which showed excellent anti-Staphylococcus aureus ability. Among them, BNP2 could effectively fight bacterial infections and promote wound healing in vivo.
抗菌光动力疗法（aPDT）是一种有效消除细菌而不诱导细菌耐药性的策略。作为典型的 aPDT 光敏剂，大多数硼二吡咯甲烷（BODIPY）都是疏水性的，纳米化对于使它们在生理介质中分散是必不可少的。最近，通过 BODIPY 的自组装而无需任何表面活性剂或助剂形成了无载体纳米颗粒（NPs），引起了人们的兴趣。为了制备无载体 NPs，BODIPY 通常需要通过复杂反应衍生为二聚体、三聚体或两亲物。从具有精确结构的 BODIPY 中获得的纯 NPs 很少。在此，通过 BODIPY 的自组装合成了 BNP1-BNP3，它们表现出优异的抗金黄色葡萄球菌能力。其中，BNP2 能够有效对抗细菌感染并促进体内伤口愈合。
