Zabihi Mohsen, Hatefi Bahareh, Ardakani Mohammad Ebrahimzadeh, Ranjbar Ali Mohammad, Mohammadi Farhad
Department of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Dermatology, School of Medicine, Shohadaye Mehrab Burn Injuries Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Complement Ther Med. 2023 May;73:102941. doi: 10.1016/j.ctim.2023.102941. Epub 2023 Mar 2.
Due to the known side effects of many synthetic drugs, the use of herbal and natural substances in treating diseases such as burns has been considered. licorice is a herbal medicine whose stem and underground roots are used in traditional medicine in many countries, including Iran, for anti-inflammatory, stomach ulcer healing, and antimicrobial purposes.
This study investigated the healing effect of hydroalcoholic extract of licorice root on the wound healing process caused by second-degree burns.
The hydroalcoholic extract of licorice was prepared in ethanol solvent, and then the licorice hydrogel product was designed using gelling compounds. Then, in a double-blinded randomized clinical trial, 50 patients with second-degree burns were selected based on inclusion criteria from the patients referred to Yazd Hospital and Isfahan Hospital. Participants were randomly divided into two groups: the control group receiving hydrogel without extract and the intervention group receiving hydrogel containing licorice root hydroalcoholic extract. The intervention lasted for 15 days, and during this period, the wound-healing process was evaluated on days 1, 3, 6, 10, and 15. Data were analyzed using SPSS software with independent T-test and Mann-Whitney U tests with a maximum error of 5 %.
The rate of inflammation (From the 3rd day to the 10th day), redness (From the 6th day to the 15th day), pain (on the 3rd day), and burning (From the 3rd day to the 15th day) of the wound in the group that used the hydrogel-containing hydroalcoholic extract of licorice root was significantly lower than in the control group (P < 0.05), and the healing process was significantly faster than the control group.
Hydroalcoholic extract of licorice root can accelerate the healing process of second-degree burns.
由于许多合成药物存在已知的副作用，人们开始考虑使用草药和天然物质来治疗烧伤等疾病。甘草是一种草药，其茎和地下根在包括伊朗在内的许多国家的传统医学中用于抗炎、治疗胃溃疡和抗菌。
本研究调查了甘草根水醇提取物对二度烧伤伤口愈合过程的愈合效果。
在乙醇溶剂中制备甘草水醇提取物，然后使用胶凝化合物设计甘草水凝胶产品。然后，在一项双盲随机临床试验中，根据纳入标准从转诊至亚兹德医院和伊斯法罕医院的患者中选择了50名二度烧伤患者。参与者被随机分为两组：对照组接受不含提取物的水凝胶，干预组接受含有甘草根水醇提取物的水凝胶。干预持续15天，在此期间，在第1、3、6、10和15天对伤口愈合过程进行评估。使用SPSS软件进行数据分析，采用独立T检验和曼-惠特尼U检验，最大误差为5%。
使用含甘草根水醇提取物水凝胶的组中，伤口的炎症发生率（从第3天到第10天）、发红程度（从第6天到第15天）、疼痛程度（第3天）和灼痛程度（从第3天到第15天）均显著低于对照组（P < 0.05），愈合过程明显快于对照组。
甘草根水醇提取物可加速二度烧伤的愈合过程。
