Vafaei F, Abdollahzadeh F
Department of Surgery, Imam Ali Hospital,North Khorasan University of Medical Sciences, Bojnurd, Iran.
Young Researchers and Elite Club, Boukan Branch, Islamic Azad University, Boukan, Iran.
J Med Life. 2015;8(Spec Iss 2):117-120.
Two thirds of all accidents and injuries leading to death all around the world occur in developing countries like Iran. One of these accidents is burn that can have unpleasant effects on the individual's body and soul. Skin wound healing is a process that happens as a result of coordination between tissues, cells, and different factors. The remaining inflammation and insufficient amount of vessel construction are among the most important causes of delayed wound healing. In recent years, jujube fruit (Zizyphus vulgaris L.) has been reported to have anti-inflammatory effects as a traditional therapeutic agent. Therefore, the present study was conducted in order to investigate the effects of jujube fruit extract on second-degree burn wound among Balb/c mice. The present empirical-interventional study included 48 Balb/c mice weighing approximately 30 +/- 3 gr. After burn wounds of 1.5 cm2 were created and second-degree burns was affirmed by a pathologist, the mice were divided into four control groups; one treated with Vaseline, one treated with silver sulfadiazine ointment, one treated with jujube fruit extract 1%, and a control group. In treatment groups, 1 gr ointment containing hydroalcoholic extract of jujube fruit was utilized twice a day until complete recovery. Afterwards, the four groups were compared with regard to the wound area and histopathology. The collected data were analyzed through one-way ANOVA and Tukey tests by using SPSS software. There was a significant difference between the intervention group and the Vaseline and control groups with regard to the percentage of wound recovery (P smaller than 0.05). The results of the study indicated that the jujube fruit extract could accelerate burn wound healing among Balb/c mice. It is recommended that further research is conducted on the effects of different doses of this medicine on laboratory animals and then on humans.
全球三分之二导致死亡的事故和伤害发生在伊朗这样的发展中国家。其中一种事故是烧伤，它会对个人的身体和心灵产生不良影响。皮肤伤口愈合是一个由组织、细胞和不同因素相互协调而发生的过程。残留炎症和血管生成不足是伤口愈合延迟的最重要原因之一。近年来，枣果（Zizyphus vulgaris L.）作为一种传统治疗剂，已被报道具有抗炎作用。因此，本研究旨在调查枣果提取物对Balb/c小鼠二度烧伤创面的影响。本实证干预研究包括48只体重约30±3克的Balb/c小鼠。在造成1.5平方厘米的烧伤创面并经病理学家确认二度烧伤后，将小鼠分为四个对照组；一组用凡士林治疗，一组用磺胺嘧啶银软膏治疗，一组用1%枣果提取物治疗，还有一个对照组。在治疗组中，每天两次使用含1克枣果水醇提取物的软膏，直至完全康复。之后，比较四组的伤口面积和组织病理学。收集的数据通过SPSS软件进行单因素方差分析和Tukey检验。干预组与凡士林组和对照组在伤口愈合百分比方面存在显著差异（P小于0.05）。研究结果表明，枣果提取物可加速Balb/c小鼠烧伤创面的愈合。建议进一步研究这种药物不同剂量对实验动物的影响，然后再研究对人类的影响。
