钯响应脂质体用于触发水相内容物的释放。
Palladium responsive liposomes for triggered release of aqueous contents.
机构信息
Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, United States.
Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, United States.
出版信息
Bioorg Med Chem Lett. 2023 Mar 15;84:129215. doi: 10.1016/j.bmcl.2023.129215. Epub 2023 Mar 2.
Palladium (Pd) is a promising metal catalyst for novel bioorthogonal chemistry and prodrug activation. This report describes the first example of palladium responsive liposomes. The key molecule is a new caged phospholipid called Alloc-PE that forms stable liposomes (large unilamellar vesicles, ∼220 nm diameter). Liposome treatment with PdCl removes the chemical cage, liberates membrane destabilizing dioleoylphosphoethanolamine (DOPE), and triggers liposome leakage of encapsulated aqueous contents. The results indicate a path towards liposomal drug delivery technologies that exploit transition metal triggered leakage.
钯（Pd）是一种有前途的新型生物正交化学和前药激活的金属催化剂。本报告描述了钯响应脂质体的第一个例子。关键分子是一种新的笼状磷脂，称为Alloc-PE，它形成稳定的脂质体（大单层囊泡，直径约 220nm）。用 PdCl 处理脂质体可去除化学笼，释放膜不稳定的二油酰基磷脂酰乙醇胺（DOPE），并触发囊封水相内容物的脂质体泄漏。结果表明，开发利用过渡金属触发泄漏的脂质体药物递送技术具有一定的前景。
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