Jiang Yanhao, Li Wenpan, Wang Zhiren, Lu Jianqin
Pharmaceutics and Pharmacokinetics Track, Skaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.
Clinical and Translational Oncology Program, NCI-Designated University of Arizona Comprehensive Cancer Center, Tucson, AZ 85721, USA.
Pharmaceutics. 2023 Dec 26;16(1):34. doi: 10.3390/pharmaceutics16010034.
Over the past several decades, liposomes have been extensively developed and used for various clinical applications such as in pharmaceutical, cosmetic, and dietetic fields, due to its versatility, biocompatibility, and biodegradability, as well as the ability to enhance the therapeutic index of free drugs. However, some challenges remain unsolved, including liposome premature leakage, manufacturing irreproducibility, and limited translation success. This article reviews various aspects of liposomes, including its advantages, major compositions, and common preparation techniques, and discusses present U.S. FDA-approved, clinical, and preclinical liposomal nanotherapeutics for treating and preventing a variety of human diseases. In addition, we summarize the significance of and challenges in liposome-enabled nanotherapeutic development and hope it provides the fundamental knowledge and concepts about liposomes and their applications and contributions in contemporary pharmaceutical advancement.
在过去几十年中，由于脂质体具有多功能性、生物相容性和可生物降解性，以及能够提高游离药物的治疗指数，因此得到了广泛的开发，并用于各种临床应用，如制药、化妆品和饮食领域。然而，一些挑战仍未得到解决，包括脂质体过早泄漏、生产不可重复性以及转化成功率有限。本文综述了脂质体的各个方面，包括其优点、主要成分和常见制备技术，并讨论了目前美国食品药品监督管理局（FDA）批准的、临床和临床前的脂质体纳米疗法，用于治疗和预防各种人类疾病。此外，我们总结了脂质体纳米疗法开发的意义和挑战，并希望它能提供有关脂质体及其在当代药物发展中的应用和贡献的基础知识和概念。
