Singh Baljit, Kumari Ankita, Sharma Diwanshi, Dhiman Abhishek, Kumar Sushil
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
Int J Biol Macromol. 2023 Apr 30;235:123856. doi: 10.1016/j.ijbiomac.2023.123856. Epub 2023 Mar 2.
Recent advancements in development of natural polymer nono-composites led to exploration of potential of gum acacia (GA) and tragacanth gum (TG) for design of silver nanoparticles (AgNPs) impregnated grafted copolymers via green approach for use in drug delivery (DD). The formation of copolymers was confirmed by UV-Vis spectroscopy, TEM, SEM, AFM, XPS, XRD, FTIR,TGA and DSC. UV-Vis spectra indicated the formation of AgNPs using GA as reducing agent. TEM, SEM, XPS and XRD revealed impregnation of AgNPs inside the copolymeric network hydrogels. TGA inferred thermal stability of polymer enhanced by grafting and incorporation of AgNPs. The non-Fickian diffusion of antibiotic drug meropenem was revealed from drug encapsulated GA-TG-(AgNPs)-cl-poly(AAm) network which were also pH responsive and release profile was fitted in Korsmeyer-Peppas kinetic model. Sustained release was due to polymer-drug interaction. The polymer-blood interaction demonstrated biocompatible characteristics of polymer. Mucoadhesive property exhibited by copolymers because of supra-molecular interactions. Antimicrobial characteristics were shown by copolymers against bacteria S. flexneri, P. auroginosa, and B. cereus.
天然聚合物纳米复合材料开发方面的最新进展促使人们探索阿拉伯胶（GA）和黄芪胶（TG）通过绿色方法设计用于药物递送（DD）的负载银纳米颗粒（AgNPs）的接枝共聚物的潜力。通过紫外可见光谱、透射电子显微镜、扫描电子显微镜、原子力显微镜、X射线光电子能谱、X射线衍射、傅里叶变换红外光谱、热重分析和差示扫描量热法证实了共聚物的形成。紫外可见光谱表明以GA作为还原剂形成了AgNPs。透射电子显微镜、扫描电子显微镜、X射线光电子能谱和X射线衍射显示AgNPs浸渍在共聚网络水凝胶内部。热重分析推断接枝和引入AgNPs增强了聚合物的热稳定性。从包封药物的GA-TG-（AgNPs）-cl-聚（丙烯酰胺）网络中揭示了抗生素药物美罗培南的非菲克扩散，该网络也具有pH响应性，释放曲线符合Korsmeyer-Peppas动力学模型。持续释放归因于聚合物与药物的相互作用。聚合物与血液的相互作用证明了聚合物的生物相容性。共聚物由于超分子相互作用而表现出粘膜粘附特性。共聚物对弗氏志贺菌、铜绿假单胞菌和蜡样芽孢杆菌显示出抗菌特性。
