Syukriani Yoni, Wulandari Ari Sri, Wanranto Busyra, Hidayat Yuyun
Department of Forensic and Legal Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Department of Forensic and Legal Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Sci Justice. 2023 Mar;63(2):229-237. doi: 10.1016/j.scijus.2023.01.003. Epub 2023 Jan 20.
The existence of the Chinese population in the predominantly Malay population in Indonesia can be traced back thousands of years, and it has been suspected that it played an essential role in the history of the Malay population origin in Maritime South East Asia. With the fact that the Malay-Indonesian population is currently predominant compared to the Chinese population in Indonesia (Chinese-Indonesian), the selection of the origin of the STRs allele frequency panel population becomes an issue in DNA profiling, including in paternity testing. This study analyses the genetic relationship between the Chinese-Indonesian and Malay-Indonesian populations and how this affects the Paternity Index (PI) calculation in paternity test cases. The study of the relationship between populations was carried out using neighbour-joining (NJ) tree analysis and multidimensional scaling (MDS) on the allele frequency panel of 19 autosomal STRs loci of Malay-Indonesian (n = 210) and Chinese-Indonesian (n = 78) populations. Four population groups were used as references: Malay-Malaysian, Filipino, Chinese, and Caucasian. An MDS analysis was also performed based on the pairwise F calculation. The combined Paternity Index (CPI) calculation was carried out on 132 paternity cases from the Malay-Indonesian population with inclusive results using a panel of allele frequencies from the six populations. The pairwise F MDS indicates a closer relationship between the Chinese-Indonesian and Malay-Indonesian compared to the Chinese population, which is in line with the CPIs comparison test. The outcome suggests that the alternative use of allele frequency database between Malay-Indonesian and Chinese-Indonesian for CPI calculations is not very influential. These results can also be considered in studying the extent of genetic assimilation between the two populations. In addition, these results support the robustness claim of multivariate analysis to represent phenomena that phylogenetic analyses may not be able to demonstrate, especially for massive panel data.
在印度尼西亚以马来人为主的人口中，华裔人口的存在可以追溯到数千年前，并且有人怀疑华裔人口在东南亚海洋地区马来人口的起源历史中发挥了重要作用。鉴于目前印度尼西亚的马来 - 印尼人口比华裔人口（印尼华人）占主导地位，在DNA分析（包括亲子鉴定）中，STR等位基因频率面板群体的来源选择成为一个问题。本研究分析了印尼华人和马来 - 印尼人之间的遗传关系，以及这如何影响亲子鉴定案例中的父权指数（PI）计算。使用邻接法（NJ）树分析和多维尺度分析（MDS），对马来 - 印尼人（n = 210）和印尼华人（n = 78）群体的19个常染色体STR基因座的等位基因频率面板进行了群体间关系研究。四个群体用作参考：马来西亚马来人、菲律宾人、中国人和高加索人。还基于成对F计算进行了MDS分析。使用来自六个群体的等位基因频率面板，对132例来自马来 - 印尼人群体的亲子鉴定案例进行了综合父权指数（CPI）计算，结果具有包容性。成对F MDS表明，与中国人相比，印尼华人和马来 - 印尼人之间的关系更密切，这与CPI比较测试结果一致。结果表明，在计算CPI时交替使用马来 - 印尼人和印尼华人的等位基因频率数据库影响不大。在研究这两个人口群体之间的基因同化程度时，也可以考虑这些结果。此外，这些结果支持多变量分析能够呈现系统发育分析可能无法证明的现象（特别是对于大量面板数据）这一稳健性主张。
