Backhaus M, Mielke F, Windt E, Grauel E L, Lukowsky A, Tausendfreund K
Klinik für Innere Medizin Theodor Brugsch, Bereiches Medizin (Charité), Humboldt-Universität zu Berlin.
Z Gesamte Inn Med. 1987 Aug 15;42(16):450-3.
The article describes a method for the quantification of plasma fibronectin (FN) by means of electroimmunodiffusion after Laurell. By this means the fibronectin concentrations of healthy, mature newborns as well as of their mothers were determined. The average FN-level of the newborns lies at 33% related to the value for adults and at 48%, respectively, related to the maternal FN-content. There is no difference between male and female newborns. The FN-concentrations of the adults stated by us with 330 and 314 mg/l, respectively, for males and females correspond to the data in literature. Furthermore, the FN-content in plasma preparations was determined, with an average value of 2,356 mg/l this was highest in the factor-VIII-concentrate. The expediency and the prerequisites for a possible fibronectin substitution are discussed.
本文描述了一种采用劳雷尔之后的电免疫扩散法对血浆纤连蛋白（FN）进行定量的方法。通过这种方法测定了健康成熟新生儿及其母亲的纤连蛋白浓度。新生儿的平均FN水平相对于成年人的值为33%，相对于母亲的FN含量分别为48%。男婴和女婴之间没有差异。我们测定的成年人的FN浓度，男性和女性分别为330和314mg/l，与文献数据相符。此外，还测定了血浆制剂中的FN含量，平均为2356mg/l，在凝血因子VIII浓缩物中含量最高。文中讨论了纤连蛋白替代的可行性和前提条件。
