Tian Bingren, Liu Jiayue
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China; Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, Macau SAR, China.
Int J Biol Macromol. 2023 Apr 30;235:123902. doi: 10.1016/j.ijbiomac.2023.123902. Epub 2023 Mar 3.
Smart stimuli-responsive materials can respond to different signals (pH, temperature, light, electricity, etc.), and they have become a hot research topic for drug delivery. As a polysaccharide polymer with excellent biocompatibility, chitosan can be obtained from diverse natural sources. Chitosan hydrogels with different stimuli-response capabilities are widely applied in the drug delivery field. This review highlights and discusses the research progress on chitosan hydrogels concerning their stimuli-responsive capabilities. The feature of various stimuli-responsive kinds of hydrogels is outlined, and their potential use of drug delivery is summarized. Furthermore, the questions and future development chances of stimuli-responsive chitosan hydrogels are analyzed by comparing the current published literature, and the directions for the intelligent development of chitosan hydrogels are discussed.
智能刺激响应材料能够对不同信号（pH值、温度、光、电等）做出响应，并且已成为药物递送领域的一个热门研究课题。壳聚糖作为一种具有优异生物相容性的多糖聚合物，可从多种天然来源获得。具有不同刺激响应能力的壳聚糖水凝胶在药物递送领域得到了广泛应用。本文综述重点介绍并讨论了壳聚糖水凝胶在刺激响应能力方面的研究进展。概述了各种刺激响应型水凝胶的特点，并总结了它们在药物递送中的潜在用途。此外，通过比较当前已发表的文献，分析了刺激响应型壳聚糖水凝胶存在的问题和未来的发展机遇，并探讨了壳聚糖水凝胶智能发展的方向。
