Iacob Andreea-Teodora, Ababei-Bobu Andra, Chirliu Oana-Maria, Lupascu Florentina Geanina, Vasincu Ioana-Mirela, Apotrosoaei Maria, Profire Bianca-Stefania, Tauser Georgiana-Roxana, Lupascu Dan, Profire Lenuta
Department of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.
Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.
Polymers (Basel). 2025 Jun 4;17(11):1566. doi: 10.3390/polym17111566.
The development of nanocarriers for drug delivery has drawn a lot of attention due to the possibility for tailored delivery to the ill region while preserving the neighboring healthy tissue. In medicine, delivering drugs safely and effectively has never been easy; therefore, the creation of surfactant-based vesicles (niosomes) to enhance medication delivery has gained attention in the past years. Niosomes (NIOs) are versatile drug delivery systems that facilitate applications varying from transdermal transport to targeted brain delivery. These self-assembling vesicular nano-carriers are formed by hydrating cholesterol, non-ionic surfactants, and other amphiphilic substances. The focus of the review is to report on the latest NIO-type formulations which also include biopolymers from the polysaccharide class, highlighting their role in the development of these drug delivery systems (DDSs). The NIO and polysaccharide types, together with the recent pharmaceutical applications such as ocular, oral, nose-to brain, pulmonary, cardiac, and transdermal drug delivery, are all thoroughly summarized in this review, which offers a comprehensive compendium of polysaccharide-based niosomal research to date. Lastly, this delivery system's limits and prospects are also examined.
用于药物递送的纳米载体的开发引起了广泛关注，因为它有可能在保护邻近健康组织的同时，将药物精准递送至患病区域。在医学领域，安全有效地递送药物绝非易事；因此，近年来，基于表面活性剂的囊泡（非离子表面活性剂囊泡）用于增强药物递送的研究受到了关注。非离子表面活性剂囊泡是多功能药物递送系统，可促进从透皮运输到靶向脑递送等各种应用。这些自组装的囊泡纳米载体由胆固醇、非离子表面活性剂和其他两亲性物质水合形成。本综述的重点是报告最新的非离子表面活性剂囊泡型制剂，其中还包括多糖类生物聚合物，强调它们在这些药物递送系统（DDS）开发中的作用。本综述全面总结了非离子表面活性剂囊泡和多糖类型，以及近期在眼部、口服、鼻脑、肺部、心脏和透皮药物递送等方面的药物应用，提供了迄今为止基于多糖的非离子表面活性剂囊泡研究的综合概要。最后，还探讨了该递送系统的局限性和前景。
