伞花萝芙木中的抗菌吲哚生物碱。

Antimicrobial indole alkaloids from Tabernaemontana corymbosa.

作者信息

Fan Kun, Zhang Lanchun, Tan Bangyin, Njateng Guy S S, Qin Malong, Guo Ruirong, Huang Xiaojuan, Ding Cai-Feng, Gao Weimin, Zhang Rongping, Yu Haofei

机构信息

School of Pharmaceutical Sciences, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

出版信息

Chin J Nat Med. 2023 Feb;21(2):146-153. doi: 10.1016/S1875-5364(23)60393-0.

DOI:10.1016/S1875-5364(23)60393-0

PMID:36871982

Abstract

Four unreported monoterpene indole alkaloids, tabernaecorymines B-E (1-4), together with twenty-one known indole alkaloids (5-25) were obtained from the stem bark of Tabernaemontana corymbosa. Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, DP4+ probability analyses and Mo(OAc)-induced electronic circular dichroism experiment. The antibacterial and antifungal activities of these compounds were evaluated and some of them showed significant activity against Staphylococcus aureus,Bacillus subtilis, Streptococcus dysgalactiae and Candida albicans.

摘要

从伞花鸡蛋花的茎皮中获得了4个未报道的单萜吲哚生物碱，即鸡蛋花胺碱B - E（1 - 4），以及21个已知的吲哚生物碱（5 - 25）。通过广泛的光谱学、量子化学计算、DP4 +概率分析和钼（乙酸根）诱导的电子圆二色性实验阐明了它们的结构和绝对构型。对这些化合物的抗菌和抗真菌活性进行了评估，其中一些对金黄色葡萄球菌、枯草芽孢杆菌、乳房链球菌和白色念珠菌表现出显著活性。