来自伞花山橙的新型沃巴西宁基-伊波加因型双吲哚生物碱。
New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa.
作者信息
Zhang Yu, Guo Lingli, Yang Guangmei, Guo Feng, Di Yingtong, Li Shunlin, Chen Duozhi, Hao Xiaojiang
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
出版信息
Fitoterapia. 2015 Jan;100:150-5. doi: 10.1016/j.fitote.2014.11.016. Epub 2014 Nov 29.
Ten vobasinyl-ibogan type bisindole alkaloids, including three new ones, tabercorines A-C (1-3), and a new natural product, 17-acetyl-tabernaecorymbosine A (4), were isolated from the twigs and leaves of Tabernaemontana corymbosa. Their structures were elucidated on the basis of spectroscopic data, and the NMR data of 17-acetyl-tabernaecorymbosine A (4) was assigned and reported for the first time. The absolute configurations of 1-4 were determined by CD exciton chirality method. All new compounds were evaluated for in vitro cytotoxicity against various human cancer cell lines. Compounds 1 and 4 showed significant inhibitory effects with IC50 values comparable to those of cisplatin.
从伞花鸡蛋花的嫩枝和叶片中分离得到了10个沃巴西宁基-伊博格型双吲哚生物碱，包括3个新化合物，伞花鸡蛋花碱A-C（1-3），以及1个新天然产物，17-乙酰基-伞花鸡蛋花碱A（4）。通过光谱数据阐明了它们的结构，并首次归属并报道了17-乙酰基-伞花鸡蛋花碱A（4）的核磁共振数据。采用圆二色激子手性方法确定了1-4的绝对构型。对所有新化合物进行了针对多种人癌细胞系的体外细胞毒性评价。化合物1和4表现出显著的抑制作用，其半数抑制浓度（IC50）值与顺铂相当。
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