从圆锥山麻杆中分离得到的单萜吲哚 N-氧化物生物碱及其抗菌活性。

Monoterpene indole N-oxide alkaloids from Tabernaemontana corymbosa and their antimicrobial activity.

机构信息

School of Pharmaceutical Science, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China.

School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, PR China.

出版信息

Fitoterapia. 2022 Apr;158:105178. doi: 10.1016/j.fitote.2022.105178. Epub 2022 Mar 14.

DOI:10.1016/j.fitote.2022.105178

PMID:35302006

Abstract

Tabernaemontana corymbosa is a traditional folk medicine. In our research, six monoterpene indole N-oxide alkaloids and their parent alkaloids were obtained from the stem bark of T. corymbosa, including seven new alkaloids (1-7) and five known alkaloids (8-12). Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, and DP4+ probability analyses. The antimicrobial activity of the obtained compounds was evaluated, among which alkaloids 4, 8, 12 showed significant antimicrobial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL, while alkaloids 11, 12 showed moderate antimicrobial activity against Bacillus subtilis with an MIC value of 25 μg/mL.

摘要

多花山竹子是一种传统的民间药物。在我们的研究中，从多花山竹子的茎皮中得到了 6 个单萜吲哚 N-氧化物生物碱及其母体生物碱，包括 7 个新生物碱（1-7）和 5 个已知生物碱（8-12）。通过广泛的光谱、量子化学计算和 DP4+概率分析确定了它们的结构和绝对构型。评价了所得到的化合物的抗菌活性，其中生物碱 4、8、12 对金黄色葡萄球菌具有显著的抗菌活性，MIC 值为 6.25μg/mL，而生物碱 11、12 对枯草芽孢杆菌具有中等的抗菌活性，MIC 值为 25μg/mL。