Department of Morphological Sciences (Histology Area), School of Medicine and Dentistry, University of Santiago de Compostela and Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain.
Epidemiology Unit, University Clinical Hospital and Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain.
J Clin Periodontol. 2023 Jun;50(6):784-795. doi: 10.1111/jcpe.13800. Epub 2023 Mar 8.
To analyse the histological structure and histomorphometric characteristics of human hard palatal mucosa in order to determine the donor site of choice for connective tissue grafts from a histological point of view.
Palatal mucosa samples from six cadaver heads were harvested at four sites: incisal, premolar, molar and tuberosity. Histological and immunohistochemical techniques were performed, as was histomorphometric analysis.
In the current study, we found that the density and size of cells were higher in the superficial papillary layer, whereas the thickness of the collagen bundles increased in the reticular layer. Excluding the epithelium, the mean percentage of lamina propria (LP) and submucosa (SM) was 37% and 63%, respectively (p < .001). LP thickness showed similar values in the incisal, premolar and molar regions, and a significantly greater thickness in tuberosity (p < .001). The thickness of SM increased from incisal to premolar and molar, disappearing in the tuberosity (p < .001).
As dense connective tissue of LP is the tissue of choice for connective tissue grafts, the best donor site from a histological point of view is tuberosity because it is composed only of a thick LP without the presence of a loose submucosal layer.
分析人类硬腭黏膜的组织学结构和组织形态学特征，以便从组织学角度确定结缔组织移植物的首选供体部位。
从 6 具尸体的 4 个部位（切牙、前磨牙、磨牙和结节）采集腭黏膜样本。进行了组织学和免疫组织化学技术以及组织形态计量学分析。
在本研究中，我们发现细胞的密度和大小在上皮下的乳头层较高，而在网状层中胶原束的厚度增加。不包括上皮，固有层（LP）和黏膜下层（SM）的平均百分比分别为 37%和 63%（p<0.001）。LP 厚度在切牙、前磨牙和磨牙区域相似，而在结节区域显著更大（p<0.001）。SM 的厚度从切牙到前磨牙和磨牙逐渐增加，在结节中消失（p<0.001）。
由于 LP 的致密结缔组织是结缔组织移植物的首选组织，因此从组织学角度来看，最好的供体部位是结节，因为它仅由无疏松黏膜下层的厚 LP 组成。
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