Gelmini G, Butturini L, Cucinotta D, Delsignore R, Coiro V
Cattedra di Clinica Medica Generale e Terapia Medica, Università degli Studi di Parma, Italy.
Acta Diabetol Lat. 1987 Jul-Sep;24(3):199-203. doi: 10.1007/BF02732038.
In order to establish whether obesity alters whole blood filterability, the corrected whole blood filtration (VRBC) was measured in 54 elderly obese women (mean age +/- SE = 67 +/- 2 years) without (n = 15) or with associated cardiovascular risk factors such as impaired glucose tolerance (IGT) (n = 11), non-insulin dependent diabetes mellitus (NIDDM) (n = 14) or hypertension (n = 14). Twenty-two age matched women with normal body weight participated as controls. VRBC values were similar in normal controls and obese women with normal glucose tolerance (NGT), whereas they were significantly lower in obese subjects with hypertension, NIDDM or IGT. When subjects with normal and impaired glucose tolerance were combined, a significant negative correlation was found between glucose incretory areas during OGTT and VRBC values. These data demonstrate that obesity per se does not alter whole blood filterability; furthermore, our results indicate that this modification is a precocious and sensitive index of altered glucose metabolism.
为了确定肥胖是否会改变全血过滤性，对54名老年肥胖女性（平均年龄±标准误=67±2岁）进行了校正全血过滤（VRBC）测量，这些女性无相关心血管危险因素（n=15）或伴有如糖耐量受损（IGT）（n=11）、非胰岛素依赖型糖尿病（NIDDM）（n=14）或高血压（n=14）等相关心血管危险因素。22名年龄匹配的体重正常女性作为对照参与研究。正常对照组和糖耐量正常（NGT）的肥胖女性的VRBC值相似，而患有高血压、NIDDM或IGT的肥胖受试者的VRBC值显著更低。当将糖耐量正常和受损的受试者合并时，发现口服葡萄糖耐量试验（OGTT）期间的葡萄糖分泌面积与VRBC值之间存在显著负相关。这些数据表明，肥胖本身不会改变全血过滤性；此外，我们的结果表明，这种改变是葡萄糖代谢改变的一个早熟且敏感的指标。
