Feng Yinrui, Liu Wenrui, Ba Te, Luo Zhenghui, Ma Yuan, Tang Guotao, Kang Y James
Regenerative Medicine Research Center, Sichuan University West China Hospital, Chengdu, Sichuan, 610041, China.
Tennessee Institute of Regenerative Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Heliyon. 2023 Feb 13;9(2):e13722. doi: 10.1016/j.heliyon.2023.e13722. eCollection 2023 Feb.
Zinc depletion is associated with alcohol-associated liver injury. We tested the hypothesis that increasing zinc availability along with alcohol consumption prevents alcohol-associated liver injury. Zinc-glutathione (ZnGSH) was synthesized and directly added to Chinese Baijiu. Mice were administered a single gastric dose of 6 g/kg ethanol in Chinese Baijiu with or without ZnGSH. ZnGSH in Chinese Baijiu did not change the likeness of the drinkers but significantly reduced the recovery time from drunkenness along with elimination of high-dose mortality. ZnGSH in Chinese Baijiu decreased serum AST and ALT, suppressed steatosis and necrosis, and increased zinc and GSH concentrations in the liver. It also increased alcohol dehydrogenase and aldehyde dehydrogenase in the liver, stomach, and intestine and reduced acetaldehyde in the liver. Thus, ZnGSH in Chinese Baijiu prevents alcohol-associated liver injury by increasing alcohol metabolism timely with alcohol consumption, providing an alternative approach to the management of alcohol-associated drinking.
锌缺乏与酒精相关性肝损伤有关。我们检验了这样一个假设，即随着酒精摄入增加锌的可利用性可预防酒精相关性肝损伤。合成了锌-谷胱甘肽（ZnGSH）并直接添加到中国白酒中。给小鼠经胃单次给予6 g/kg乙醇的中国白酒，同时添加或不添加ZnGSH。中国白酒中的ZnGSH并未改变饮酒者的喜好，但显著缩短了醉酒后的恢复时间，并消除了高剂量酒精导致的死亡。中国白酒中的ZnGSH降低了血清天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT），抑制了脂肪变性和坏死，并增加了肝脏中锌和谷胱甘肽（GSH）的浓度。它还增加了肝脏、胃和肠道中的乙醇脱氢酶和乙醛脱氢酶，并降低了肝脏中的乙醛含量。因此，中国白酒中的ZnGSH通过与酒精摄入同步及时增加酒精代谢来预防酒精相关性肝损伤，为酒精相关性饮酒的管理提供了一种替代方法。
