Tartaglione A, Oneto A, Bandini F, Spadavecchia L, Gandolfo E, Favale E
Department of Neurology, University of Genova, Italy.
Acta Neurol Scand. 1987 Oct;76(4):246-50. doi: 10.1111/j.1600-0404.1987.tb03575.x.
The incidence of a delayed P100 component of the VEP after checkerboard stimulation in probable or possible multiple sclerosis (MS) without history, signs or symptoms of optic neuritis is not significantly different from that found in other neurological disorders in which the visual system is unaffected. This reduces the diagnostic validity of a delayed P100 as evidence of "silent" plaques in the optic pathway, at least in suspected MS. The use of grating increases the VEP sensitivity in the MS group, but it still leaves more than a 30% chance of error in attributing a delayed P100 to a demyelinating disorder. In this respect the discordant behaviour of checkerboard and grating responses may represent a useful clue.
在无视神经炎病史、体征或症状的可能或疑似多发性硬化症（MS）患者中，棋盘格刺激后视觉诱发电位（VEP）的P100成分延迟发生率与视觉系统未受影响的其他神经系统疾病并无显著差异。这降低了延迟P100作为视神经通路中“无症状”斑块证据的诊断效度，至少在疑似MS中是如此。使用光栅可提高MS组中VEP的敏感性，但将延迟P100归因于脱髓鞘疾病时仍有超过30%的错误几率。在这方面，棋盘格和光栅反应的不一致行为可能是一个有用的线索。
