Tanei Takafumi, Maesawa Satoshi, Nishimura Yusuke, Nagashima Yoshitaka, Ishizaki Tomotaka, Mutoh Manabu, Ito Yoshiki, Saito Ryuta
Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
NMC Case Rep J. 2023 Feb 9;10:15-20. doi: 10.2176/jns-nmc.2022-0336. eCollection 2023.
Central poststroke pain is a chronic, intractable, central neuropathic pain. Spinal cord stimulation is a neuromodulation therapy for chronic neuropathic pain. The conventional stimulation method induces a sense of paresthesia. Fast-acting subperception therapy is one of the latest new stimulation methods without paresthesia. A case of achieving pain relief of central poststroke pain affecting both the arm and leg on one side by double-independent dual-lead spinal cord stimulation using fast-acting subperception therapy stimulation is presented. A 67-year-old woman had central poststroke pain due to a right thalamic hemorrhage. The numerical rating scale scores of the left arm and leg were 6 and 7, respectively. Using dual-lead stimulation at the Th 9-11 levels, a spinal cord stimulation trial was performed. Fast-acting subperception therapy stimulation achieved pain reduction in the left leg from 7 to 3. Therefore, a pulse generator was implanted, and the pain relief continued for 6 months. Then, two additional leads were implanted at the C 3-5 levels, and pain in the arm decreased from 6 to 4. Independent setting and adjustments of the dual-lead stimulation were required because the thresholds of paresthesia perception were significantly different. To achieve pain relief in both the arm and leg, double-independent dual-lead stimulation placed at cervical and thoracic levels is an effective treatment. Fast-acting subperception therapy stimulation may be effective for central poststroke pain, especially in cases where the paresthesia is perceived as uncomfortable or the conventional stimulation itself is ineffective.
脑卒中后中枢性疼痛是一种慢性、顽固性中枢神经性疼痛。脊髓刺激是一种用于慢性神经性疼痛的神经调节疗法。传统的刺激方法会诱发感觉异常。快速起效的阈下感知疗法是最新的无感觉异常的新刺激方法之一。本文介绍了一例采用快速起效的阈下感知疗法刺激的双独立双导联脊髓刺激术,使一侧手臂和腿部均受影响的脑卒中后中枢性疼痛得到缓解的病例。一名67岁女性因右侧丘脑出血患有脑卒中后中枢性疼痛。左臂和左腿的数字评分量表得分分别为6分和7分。在胸9 - 11节段采用双导联刺激进行脊髓刺激试验。快速起效的阈下感知疗法刺激使左腿疼痛评分从7分降至3分。因此,植入了脉冲发生器,疼痛缓解持续了6个月。然后,在颈3 - 5节段又植入了两根导联,手臂疼痛从6分降至4分。由于感觉异常感知阈值存在显著差异,需要对双导联刺激进行独立设置和调整。为使手臂和腿部均实现疼痛缓解,在颈段和胸段放置双独立双导联刺激是一种有效的治疗方法。快速起效的阈下感知疗法刺激可能对脑卒中后中枢性疼痛有效,尤其是在感觉异常被认为不舒服或传统刺激本身无效的情况下。