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成功应用快速起效亚感知疗法治疗 Chiari 畸形 1 型伴脊髓空洞术后神经病理性疼痛的脊髓刺激:病例报告及文献复习。

Successful spinal cord stimulation using fast-acting sub-perception therapy for postoperative neuropathic pain of syringomyelia with Chiari malformation type 1: a case report and literature review.

机构信息

Department of Neurosurgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato- Ku, Tokyo, 105-8461, Japan.

Department of Anesthesiology, Pain Management, The Jikei University School of Medicine, Tokyo, Japan.

出版信息

BMC Neurol. 2024 Aug 13;24(1):284. doi: 10.1186/s12883-024-03789-8.

Abstract

BACKGROUND

Central neuropathic pain after foramen magnum decompression (FMD) for Chiari malformation type 1 (CM-1) with syringomyelia can be residual and refractory. Here we present a case of refractory central neuropathic pain after FMD in a CM-1 patient with syringomyelia who achieved improvements in pain following spinal cord stimulation (SCS) using fast-acting sub-perception therapy (FAST™).

CASE PRESENTATION

A 76-year-old woman presented with a history of several years of bilateral upper extremity and chest-back pain. CM-1 and syringomyelia were diagnosed. The pain proved drug resistant, so FMD was performed for pain relief. After FMD, magnetic resonance imaging showed shrinkage of the syrinx. Pain was relieved, but bilateral finger, upper arm and thoracic back pain flared-up 10 months later. Due to pharmacotherapy resistance, SCS was planned for the purpose of improving pain. A percutaneous trial of SCS showed no improvement of pain with conventional SCS alone or in combination with Contour™, but the combination of FAST™ and Contour™ did improve pain. Three years after FMD, percutaneous leads and an implantable pulse generator were implanted. The program was set to FAST™ and Contour™. After implantation, pain as assessed using the McGill Pain Questionnaire and visual analog scale was relieved even after reducing dosages of analgesic. No adverse events were encountered.

CONCLUSION

Percutaneously implanted SCS using FAST™ may be effective for refractory pain after FMD for CM-1 with syringomyelia.

摘要

背景

颅颈交界区减压术(FMD)治疗 Chiari 畸形 1 型(CM-1)伴脊髓空洞症后可能残留和难治性中枢性神经痛。在此,我们报告一例 FMD 治疗 CM-1 伴脊髓空洞症患者后出现难治性中枢性神经痛的病例,该患者在脊髓刺激(SCS)中使用快速起效亚感知治疗(FAST™)后疼痛得到改善。

病例介绍

一名 76 岁女性,有多年双侧上肢和胸背部疼痛病史。诊断为 CM-1 和脊髓空洞症。疼痛被证明是耐药的,因此进行了 FMD 以缓解疼痛。FMD 后,磁共振成像显示脊髓空洞缩小。疼痛缓解,但双侧手指、上臂和胸背部疼痛 10 个月后加重。由于药物治疗耐药,计划进行 SCS 以改善疼痛。SCS 的经皮试验显示,单独使用常规 SCS 或与 Contour™联合使用不能改善疼痛,但 FAST™和 Contour™的联合使用确实改善了疼痛。FMD 后 3 年,进行了经皮导丝和可植入脉冲发生器的植入。方案设置为 FAST™和 Contour™。植入后,即使减少了镇痛药剂量,使用麦吉尔疼痛问卷和视觉模拟量表评估的疼痛也得到了缓解。未发生不良事件。

结论

使用 FAST™的经皮植入式 SCS 可能对 FMD 治疗 CM-1 伴脊髓空洞症后难治性疼痛有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebfc/11320895/8395297a7efd/12883_2024_3789_Fig1_HTML.jpg

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