Miller E, Berrios G E, Politynska B
Department of Psychiatry, Addenbrooke's Hospital, Cambridge, England.
Acta Neurol Scand. 1987 Oct;76(4):278-82. doi: 10.1111/j.1600-0404.1987.tb03581.x.
Seventy-eight subjects suffering from idiopathic Parkinson's disease were studied in 2 separate groups to test the hypothesis that benzhexol affects memory. In study A, 54 subjects were tested by means of a free recall technique; in study B, 24 subjects were given a signal detection memory task. Both studies yielded significant correlations between memory impairment and dosage levels of benzhexol. No correlation was found between memory status and dosage of levodopa, duration of illness or Hamilton depression scores. The implications of these findings are discussed.
78名特发性帕金森病患者被分为2个独立组进行研究，以检验苯海索会影响记忆这一假设。在研究A中，54名受试者通过自由回忆技术进行测试；在研究B中，24名受试者接受了信号检测记忆任务。两项研究均得出记忆损害与苯海索剂量水平之间存在显著相关性。未发现记忆状态与左旋多巴剂量、病程或汉密尔顿抑郁评分之间存在相关性。本文讨论了这些发现的意义。
