帕金森病中的抗胆碱能戒断与苯海索治疗
Anticholinergic withdrawal and benzhexol treatment in Parkinson's disease.
作者信息
Horrocks P M, Vicary D J, Rees J E, Parkes J D, Marsden C D
出版信息
J Neurol Neurosurg Psychiatry. 1973 Dec;36(6):936-41. doi: 10.1136/jnnp.36.6.936.
Abstract
The effects of slow withdrawal of anticholinergic medication and addition of benzhexol (8 mg/day) have been studied in patients with Parkinson's disease on stable levodopa therapy. Withdrawal of anticholinergic drugs led to measurable and often severe deterioration in about two-thirds of patients. Addition of benzhexol produced a slight but definite additional improvement in those patients in whom anticholinergics were withdrawn before the trial. Anticholinergic drugs thus still have a part to play in the treatment of Parkinson's disease, for they produce benefit in addition to that provided by levodopa.
摘要
在接受稳定左旋多巴治疗的帕金森病患者中，研究了抗胆碱能药物缓慢撤药及加用苄托品（8毫克/天）的效果。停用抗胆碱能药物导致约三分之二的患者出现可测量且往往较为严重的病情恶化。对于那些在试验前停用抗胆碱能药物的患者，加用苄托品产生了轻微但明确的额外改善。因此，抗胆碱能药物在帕金森病的治疗中仍有作用，因为它们除了左旋多巴所提供的益处外，还能产生额外疗效。
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本文引用的文献
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Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action.抗帕金森病药物：抑制纹状体中多巴胺摄取作为一种可能的作用机制。
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Treatment of Parkinson's disease with levodopa combined with L-alpha-methyldopahydrazine, an inhibitor of extracerebral DOPA decarboxylase.左旋多巴联合脑外多巴脱羧酶抑制剂L-α-甲基多巴肼治疗帕金森病。
J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):10-4. doi: 10.1136/jnnp.36.1.10.
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