Téllez I, Cabello A, Franch O, Ricoy J R
Department of Pathology (Neuropathology), 1. de Octubre, Hospital, Complutense University School of Medicine, Madrid, Spain.
Acta Neuropathol. 1987;74(4):354-61. doi: 10.1007/BF00687212.
Five patients died of a severe neuromyopathy months after the ingestion of adulterated rapeseed oil. These patients were selected for this study due to the presence of striking chromatolytic lesions in symmetric and scattered nuclei of the brain stem, including the locus coeruleus, midline raphe, lateral reticular nuclei of the medulla and cuneate nuclei. Two of the five cases, in addition to these topographic levels of involvement, had remarkable chromatolysis, vacuolar degeneration and heavy silver impregnation of the swollen perykarya and proximal dendrites in the nuclei of the basis pontis. In this paper we analyze the features of the chromatolytic lesion and suggest that the neuronal pathology observed in these cases is an example of irreversible chromatolysis involving vacuolization and filamentous proliferation as final events of the chromatolytic process. The cause of the cell degeneration in the toxic oil syndrome (TOS) is yet undetermined. Chromatolysis in this disease may be the result of a neurotoxic action of the toxic factor in the adulterated oil.
五名患者在摄入掺假菜籽油数月后死于严重的神经肌肉病。由于在包括蓝斑、中缝核、延髓外侧网状核和楔状核在内的脑干对称且散在的细胞核中存在明显的染色质溶解病变，这些患者被选入本研究。五例中的两例，除了这些受累的解剖部位外，脑桥基底部细胞核中肿胀的核周体和近端树突有明显的染色质溶解、空泡变性和重度银浸染。在本文中，我们分析了染色质溶解病变的特征，并认为在这些病例中观察到的神经元病理学是不可逆染色质溶解的一个例子，其涉及空泡化和丝状增殖，作为染色质溶解过程的最终事件。有毒油综合征（TOS）中细胞变性的原因尚未确定。这种疾病中的染色质溶解可能是掺假油中有毒因子神经毒性作用的结果。
