Jones H B, Cavanagh J B
Neuropathol Appl Neurobiol. 1981 Nov-Dec;7(6):489-501. doi: 10.1111/j.1365-2990.1981.tb00248.x.
The early effects of acute isoniazid intoxication and the early responses of the neuron to axotomy have been compared in lumbar spinal ganglion cells in the rat. The cells were studied by light and electron microscopy during the 4 days after a single oral dose (2g/kg) of isoniazid and for four days after application of a tight ligature to the sciatic nerve at the level of the sciatic notch. After axotomy a greater proportion of cells showed changes visible by light and electron microscopy than after INH. Small dark neurons were affected more rapidly and more severely by both insults than the large light cells as evidenced principally by changes in their ribosomal organization. Large light cells showed little response to INH. The first response to axotomy was visible about 12 h after injury. The response to INH began 24 h after the single oral dose. The early cell responses to INH therefore apparently precede axon degeneration which is first seen 72 h later and are thus probably a direct toxic effect.
对大鼠腰脊髓神经节细胞中急性异烟肼中毒的早期效应以及神经元对轴突切断术的早期反应进行了比较。在单次口服剂量（2g/kg）异烟肼后的4天内，以及在坐骨切迹水平对坐骨神经施加紧密结扎后的4天内，通过光学显微镜和电子显微镜对细胞进行了研究。轴突切断术后，与异烟肼作用后相比，有更大比例的细胞在光学显微镜和电子显微镜下呈现出可见变化。小的深色神经元比大的浅色细胞受这两种损伤的影响更快、更严重，主要表现为核糖体组织的变化。大的浅色细胞对异烟肼几乎没有反应。对轴突切断术的首次反应在损伤后约12小时可见。对异烟肼的反应在单次口服剂量后24小时开始。因此，细胞对异烟肼的早期反应显然先于轴突退变，轴突退变最早在72小时后出现，所以这可能是一种直接毒性作用。
