Ola Idris Olasunmbo, Okunowo Adeyemi Adebola, Habeebu Muhammad Yaqub, Miao Jonasson Junmei
Global Health Program, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Departments of Clinical and Community Service, The Blue-Pink Center for Women's Health, Lagos, Nigeria.
Front Oncol. 2023 Feb 16;13:1105649. doi: 10.3389/fonc.2023.1105649. eCollection 2023.
Cervical cancer (CCa) is the fourth most frequent and a common cause of cancer mortality in women, the majority of whom live in low- and middle-income countries. Data on CCa mortality and its determinants have been poorly studied in Nigeria, resulting in a paucity of information that can assist patient management and cancer control policy.
The purpose of this study was to assess the mortality rate among CCa patients in Nigeria as well as the major factors influencing CCa mortality.
Data from the medical records of 343 CCa patients seen at the Lagos University Teaching Hospital and NSIA-LUTH Cancer Center from 2015 to 2021 were used in a retrospective cohort analysis. The hazard ratios (HR) and confidence intervals (CI) associated with the exposure variables and CCa mortality were calculated using Cox proportional hazard regression.
The CCa mortality rate was 30.5 per 100 women-years after 2.2 years of median follow-up. Clinical factors such as HIV/AIDS (adjusted HR [aHR]: 11.9; 95% CI: 4.6, 30.4), advanced clinical stage (aHR: 2.7; 95% CI: 1.5, 4.7), and anemia at presentation (aHR: 1.8; 95% CI: 1.1, 3.0) were associated with a higher mortality risk, as were non-clinical factors such as age at diagnosis >50 years (aHR: 1.4; 95% CI: 1.0, 1.9) and family history of CCa (aHR: 3.5; 95%CI: 1.1, 11.1).
CCa has a high mortality rate in Nigeria. Incorporating these clinical and non-clinical factors into CCa management and control policies may improve women's outcomes.
宫颈癌（CCa）是女性中第四大常见癌症，也是癌症死亡的常见原因，其中大多数患者生活在低收入和中等收入国家。在尼日利亚，关于宫颈癌死亡率及其决定因素的数据研究较少，导致缺乏有助于患者管理和癌症控制政策的信息。
本研究的目的是评估尼日利亚宫颈癌患者的死亡率以及影响宫颈癌死亡率的主要因素。
对2015年至2021年在拉各斯大学教学医院和NSIA-LUTH癌症中心就诊的343例宫颈癌患者的病历数据进行回顾性队列分析。使用Cox比例风险回归计算与暴露变量和宫颈癌死亡率相关的风险比（HR）和置信区间（CI）。
中位随访2.2年后，宫颈癌死亡率为每100妇女年30.5例。临床因素如艾滋病毒/艾滋病（调整后HR[aHR]：11.9；95%CI：4.6，30.4）、晚期临床分期（aHR：2.7；95%CI：1.5，4.7）和就诊时贫血（aHR：1.8；95%CI：1.1，3.0）与较高的死亡风险相关，非临床因素如诊断时年龄>50岁（aHR：1.4；95%CI：1.0，1.9）和宫颈癌家族史（aHR：3.5；95%CI：1.1，11.1）也与较高的死亡风险相关。
在尼日利亚，宫颈癌死亡率很高。将这些临床和非临床因素纳入宫颈癌管理和控制政策可能会改善女性的治疗结果。
