马来酸哌克昔林与氧烯洛尔治疗心绞痛患者的对照试验。
Comparative trial of perhexiline maleate and oxprenolol in patients with angina pectoris.
作者信息
Pilcher J
出版信息
Postgrad Med J. 1978 Oct;54(636):663-7. doi: 10.1136/pgmj.54.636.663.
A random single-blind study of oxprenolol against perhexiline has been undertaken in angina pectoris. Both drugs were effective in treatment (P less than 0.01) but perhexiline was better than oxprenolol (P less than 0.05), 12 of the 14 patients preferring perhexiline. Offset against this was the greater incidence of side effects with perhexiline, including one patient who later developed peripheral neuropathy. Despite the greater efficacy of perhexiline, it is suggested that side effects should preclude its routine prescription as a drug of first choice in angina pectoris. It should remain of value in the special situations of resistant angina and angina with heart failure or bronchospasm, when its use should be carefully monitored for these side effects.
已针对心绞痛患者开展了一项比较氧烯洛尔与哌克昔林的随机单盲研究。两种药物治疗均有效（P<0.01），但哌克昔林优于氧烯洛尔（P<0.05），14名患者中有12名更倾向于使用哌克昔林。与之相对的是，哌克昔林的副作用发生率更高，其中包括一名后来出现周围神经病变的患者。尽管哌克昔林疗效更佳，但有观点认为，其副作用应使其不能作为心绞痛的首选常规用药。在顽固性心绞痛以及伴有心力衰竭或支气管痉挛的心绞痛等特殊情况下，它仍具有价值，不过使用时应密切监测这些副作用。
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