肾上腺素能β受体阻滞剂在心绞痛治疗中的比较。
Comparison of adrenergic beta-blocking drugs in angina pectoris.
作者信息
Sharma B, Meeran M K, Galvin M C, Tulpule A T, Whitaker W, Taylor S H
出版信息
Br Med J. 1971 Jul 17;3(5767):152-5. doi: 10.1136/bmj.3.5767.152.
The symptomatic, electrocardiographic, and haemodynamic effects of two adrenergic beta-blocking drugs, oxprenolol and propranolol, have been compared in equipotent intravenous doses in six patients with uncomplicated angina pectoris during treadmill exercise. The method of comparison included double-blind assessment and analysis with placebo control and randomized serial comparison in each patient. Both drugs produced an equal amelioration in symptoms in most of the patients. This was closely correlated with improvement in the electrocardiographic changes and a significant reduction in the exercising heart rate and systemic arterial pressure. This method of double-blind combined subjective and objective assessment carries distinct advantages in the comparative assessment of drug treatments in angina pectoris.
在六例无并发症的心绞痛患者进行跑步机运动期间，以等效静脉剂量比较了两种肾上腺素能β受体阻滞剂氧烯洛尔和普萘洛尔的症状、心电图及血流动力学效应。比较方法包括双盲评估以及安慰剂对照分析，并在每位患者中进行随机序列比较。两种药物在大多数患者中均使症状得到同等程度的改善。这与心电图变化的改善密切相关，且运动心率和体动脉压显著降低。这种双盲结合主观与客观评估的方法在心绞痛药物治疗的比较评估中具有明显优势。
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