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托珠单抗联合糖皮质激素成功治疗肉芽肿性多血管炎：一例报告

Successful treatment of granulomatosis with polyangiitis using tocilizumab combined with glucocorticoids: A case report.

作者信息

Tang Peng-Fang, Xu Long-Chuan, Hong Wen-Ting, Shi Hong-Ying

机构信息

Department of Rheumatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.

Department of Pathology, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.

出版信息

World J Clin Cases. 2023 Feb 16;11(5):1144-1151. doi: 10.12998/wjcc.v11.i5.1144.

DOI:10.12998/wjcc.v11.i5.1144
PMID:36874435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9979291/
Abstract

BACKGROUND

Tocilizumab is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor that is commonly used to treat large vessel vasculitis and antineutrophil cytoplasmic antibody-related small vessel vasculitis. However, tocilizumab in combination with glucocorticoids for successfully treating granulomatosis with polyangiitis (GPA) has rarely been reported.

CASE SUMMARY

Here, we report a 40-year-old male patient who suffered GPA for 4 years. He was treated with multiple rounds of drugs, including cyclophosphamide, Tripterygium wilfordii, mycophenolate mofetil, and belimumab, with no improvement. In addition, he exhibited persistently high IL-6 levels. After tocilizumab treatment, his symptoms improved, and his inflammatory marker levels returned to normal.

CONCLUSION

Tocilizumab may be effective for treating GPA.

摘要

背景

托珠单抗是一种抗白细胞介素-6（IL-6）受体的人源化单克隆抗体，常用于治疗大血管血管炎和抗中性粒细胞胞浆抗体相关的小血管血管炎。然而，托珠单抗联合糖皮质激素成功治疗肉芽肿性多血管炎（GPA）的报道很少。

病例摘要

在此，我们报告一名40岁男性患者，他患GPA已4年。他接受了多轮药物治疗，包括环磷酰胺、雷公藤、霉酚酸酯和贝利尤单抗，但病情无改善。此外，他的IL-6水平持续升高。托珠单抗治疗后，他的症状有所改善，炎症标志物水平恢复正常。

结论

托珠单抗可能对治疗GPA有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8613/9979291/df1167df0bc8/WJCC-11-1144-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8613/9979291/4651b472cecc/WJCC-11-1144-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8613/9979291/86ab3850b067/WJCC-11-1144-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8613/9979291/df1167df0bc8/WJCC-11-1144-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8613/9979291/4651b472cecc/WJCC-11-1144-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8613/9979291/86ab3850b067/WJCC-11-1144-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8613/9979291/df1167df0bc8/WJCC-11-1144-g003.jpg

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Nephrol Dial Transplant. 2022 Oct 19;37(11):2190-2200. doi: 10.1093/ndt/gfab357.
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The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis.血清白细胞介素-6 水平与抗中性粒细胞胞浆抗体相关性血管炎临床结局的相关性。
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