Dai Zhang-Yi, Shen Cheng, Mi Xing-Qi, Pu Qiang
Department of Thoracic Surgery, Sichuan University West China Medical Center, Chengdu, China.
Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu, China.
Front Surg. 2023 Feb 17;10:1077492. doi: 10.3389/fsurg.2023.1077492. eCollection 2023.
Indocyanine green (ICG) is a nontoxic, albumin-bound, liver-metabolized fluorescent iodide dye that has been widely utilized in clinical applications since the mid-1950s. However, after the 1970s, in-depth research on the fluorescence properties of ICG greatly expanded its application in the medical field.
In our mini-review, we searched the relevant literature on common oncology surgeries from PubMed, including lung cancer, breast cancer, gastric cancer, colorectal cancer, liver cancer, and pituitary tumors, using keywords such as indocyanine green, fluorescence imaging technology, and near-infrared fluorescence imaging. In addition, the application of targeted ICG photothermal technology in tumor therapy is briefly mentioned.
In this mini-review, we analyzed studies on ICG fluorescence imaging in common surgical oncology and offered a thorough analysis of each form of cancer or tumor.
ICG has demonstrated significant potential in the detection and treatment of tumors in current clinical practice, although many applications are still in the preliminary stages, and multicenter studies are still required to more precisely define its indications, effectiveness, and safety.
吲哚菁绿（ICG）是一种无毒、与白蛋白结合、经肝脏代谢的荧光碘化物染料，自20世纪50年代中期以来已广泛应用于临床。然而，20世纪70年代以后，对ICG荧光特性的深入研究极大地扩展了其在医学领域的应用。
在我们的小型综述中，我们使用吲哚菁绿、荧光成像技术和近红外荧光成像等关键词，在PubMed上搜索了有关常见肿瘤外科手术的相关文献，包括肺癌、乳腺癌、胃癌、结直肠癌、肝癌和垂体肿瘤。此外，还简要提及了靶向ICG光热技术在肿瘤治疗中的应用。
在本小型综述中，我们分析了ICG荧光成像在常见肿瘤外科手术中的研究，并对每种癌症或肿瘤形式进行了全面分析。
尽管目前许多应用仍处于初步阶段，且仍需要多中心研究来更精确地确定其适应症、有效性和安全性，但ICG在当前临床实践中的肿瘤检测和治疗方面已显示出巨大潜力。
