Wisch Julie K, Gordon Brian A, Boerwinkle Anna H, Luckett Patrick H, Bollinger James G, Ovod Vitaliy, Li Yan, Henson Rachel L, West Tim, Meyer Mathew R, Kirmess Kristopher M, Benzinger Tammie L S, Fagan Anne M, Morris John C, Bateman Randall J, Ances Beau M, Schindler Suzanne E
Department of Neurology Washington University in Saint Louis St. Louis Missouri USA.
Department of Radiology Washington University in Saint Louis St. Louis Missouri USA.
Alzheimers Dement (Amst). 2023 Mar 2;15(1):e12405. doi: 10.1002/dad2.12405. eCollection 2023 Jan-Mar.
Continuous measures of amyloid burden as measured by positron emission tomography (PET) are being used increasingly to stage Alzheimer's disease (AD). This study examined whether cerebrospinal fluid (CSF) and plasma amyloid beta (Aβ)42/Aβ40 could predict continuous values for amyloid PET.
CSF Aβ42 and Aβ40 were measured with automated immunoassays. Plasma Aβ42 and Aβ40 were measured with an immunoprecipitation-mass spectrometry assay. Amyloid PET was performed with Pittsburgh compound B (PiB). The continuous relationships of CSF and plasma Aβ42/Aβ40 with amyloid PET burden were modeled.
Most participants were cognitively normal (427 of 491 [87%]) and the mean age was 69.0 ± 8.8 years. CSF Aβ42/Aβ40 predicted amyloid PET burden until a relatively high level of amyloid accumulation (69.8 Centiloids), whereas plasma Aβ42/Aβ40 predicted amyloid PET burden until a lower level (33.4 Centiloids).
CSF Aβ42/Aβ40 predicts the continuous level of amyloid plaque burden over a wider range than plasma Aβ42/Aβ40 and may be useful in AD staging.
Cerebrospinal fluid (CSF) amyloid beta (Aβ)42/Aβ40 predicts continuous amyloid positron emission tomography (PET) values up to a relatively high burden.Plasma Aβ42/Aβ40 is a comparatively dichotomous measure of brain amyloidosis.Models can predict regional amyloid PET burden based on CSF Aβ42/Aβ40.CSF Aβ42/Aβ40 may be useful in staging AD.
通过正电子发射断层扫描（PET）测量的淀粉样蛋白负荷的连续指标越来越多地用于阿尔茨海默病（AD）的分期。本研究探讨了脑脊液（CSF）和血浆淀粉样蛋白β（Aβ）42/Aβ40是否能够预测淀粉样蛋白PET的连续值。
采用自动免疫分析法测量脑脊液Aβ42和Aβ40。采用免疫沉淀-质谱分析法测量血浆Aβ42和Aβ40。使用匹兹堡化合物B（PiB）进行淀粉样蛋白PET检查。对脑脊液和血浆Aβ42/Aβ40与淀粉样蛋白PET负荷之间的连续关系进行建模。
大多数参与者认知正常（491例中的427例[87%]），平均年龄为69.0±8.8岁。脑脊液Aβ42/Aβ40可预测淀粉样蛋白PET负荷，直至淀粉样蛋白积累达到相对较高水平（69.8 Centiloids），而血浆Aβ42/Aβ40可预测淀粉样蛋白PET负荷直至较低水平（33.4 Centiloids）。
脑脊液Aβ42/Aβ40比血浆Aβ42/Aβ40能在更宽范围内预测淀粉样斑块负荷的连续水平，可能对AD分期有用。
脑脊液（CSF）淀粉样蛋白β（Aβ）42/Aβ40可预测连续的淀粉样蛋白正电子发射断层扫描（PET）值，直至负担相对较高。血浆Aβ42/Aβ40是脑淀粉样变性的相对二分法测量指标。模型可根据脑脊液Aβ42/Aβ40预测局部淀粉样蛋白PET负荷。脑脊液Aβ42/Aβ40可能对AD分期有用。
