Suppr超能文献

改良 Blumgart 导管对黏膜吻合术与套入式胰肠吻合术围手术期结局的比较研究

Comparative Study of Perioperative Outcomes Between Modified Blumgart Duct to Mucosa and Dunking Pancreaticojejunostomy.

作者信息

Adhikari Krishna M, Sharma Deepak, Dahal Romi, Kandel Bishnu P, Lakhey Paleswan J

机构信息

Department of Surgical Gastroenterology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, NPL.

出版信息

Cureus. 2023 Jan 30;15(1):e34418. doi: 10.7759/cureus.34418. eCollection 2023 Jan.

Abstract

BACKGROUND

Pancreaticojejunostomy (PJ) is the ''Achilles heel" of pancreaticoduodenectomy (PD) which affects perioperative as well as oncological outcomes. However, there is a lack of information about the superiority of the type of anastomosis in terms of overall morbidity and postoperative pancreatic fistula (POPF) after PD. Here, we compare the outcomes of modified Blumgart PJ with the dunking technique of PJ.

METHODOLOGY

A case-control study of a prospectively maintained database of 25 consecutive patients undergoing modified Blumgart PJ (study group) and 25 patients who underwent continuous dunking PJ (control group) between January 2018 to April 2021 was done. Between groups, comparisons were made for the duration of surgery, intraoperative blood loss, original fistula risk score, overall complications as graded by Clavien Dindo (CD), POPF, post pancreatectomy haemorrhage (PPH), delayed gastric emptying (DGE), and 30-day mortality at 95% confidence level.

RESULTS

Among 50 patients, 30 (60%) were male. The most common indication for PD was ampullary carcinoma (44% in the study group vs. 60% in the control group). The duration of surgery was approximately 41 minutes longer in the study group compared to the control (p = 0.02), while the intraoperative blood loss was similar between the two groups (496.00 ± 226.35 ml vs 508.00 ± 180.67 ml, p = 0.84). While there was no significant difference in mean fistula risk score between the two groups, the POPF (8% vs 32%, p = 0.03), PPH (0% vs 20%, p =0.02), and overall major complications (CD≥ III) according to CD Grading (12% vs 40%, p = 0.02) were significantly lower in the study group. Similarly, the duration of hospital stay in the study group was 4.64 days shorter than the control group (p = 0.001). However, there was no significant difference in the 30-day mortality between the two groups.

CONCLUSIONS

Modified Blumgart pancreaticojejunostomy has better perioperative outcomes in terms of procedure-specific complications like POPF, PPH, overall major postoperative complications, and duration of hospital stay.

摘要

背景

胰肠吻合术(PJ)是胰十二指肠切除术(PD)的“阿喀琉斯之踵”,会影响围手术期及肿瘤学结局。然而,关于PD术后不同吻合方式在总体发病率和术后胰瘘(POPF)方面的优势,目前缺乏相关信息。在此,我们比较改良Blumgart PJ与“浸泡法”PJ的手术效果。

方法

对前瞻性维护的数据库进行病例对照研究,该数据库纳入了2018年1月至2021年4月期间连续接受改良Blumgart PJ手术的25例患者(研究组)和25例接受连续“浸泡法”PJ手术的患者(对照组)。在两组之间,比较手术时长、术中失血量、初始瘘风险评分、根据Clavien-Dindo(CD)分级的总体并发症、POPF、胰十二指肠切除术后出血(PPH)、胃排空延迟(DGE)以及95%置信水平下的30天死亡率。

结果

50例患者中,30例(60%)为男性。PD最常见的适应证是壶腹癌(研究组为44%,对照组为60%)。研究组的手术时长比对照组约长41分钟(p = 0.02),而两组的术中失血量相似(496.00 ± 226.35 ml对508.00 ± 180.67 ml,p = 0.84)。虽然两组的平均瘘风险评分无显著差异,但研究组的POPF(8%对32%,p = 0.03)、PPH(0%对20%,p = 0.02)以及根据CD分级的总体严重并发症(CD≥III)(12%对40%,p = 0.02)显著更低。同样,研究组的住院时长比对照组短4.64天(p = 0.001)。然而,两组之间的30天死亡率无显著差异。

结论

改良Blumgart胰肠吻合术在POPF、PPH、总体术后严重并发症以及住院时长等特定手术并发症方面具有更好的围手术期效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e982/9978053/69ce9254f3b8/cureus-0015-00000034418-i01.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验