Karoutas G, Tsitsopoulos P, Taskos N, Karacostas D, Tzotzoras T, Liapis J, Logothetis J
Department of Neurology, Aristotelian University School of Medicine, Agios Dimitrios Hospital, Thessaloniki, Greece.
Acta Neurochir (Wien). 1987;88(3-4):135-41. doi: 10.1007/BF01404150.
Our study was carried out in 34 rabbits which were divided into three groups (A, B, C). In group A (10 animals), a mid-laminectomy of the first lumbar (L1) vertebra was performed and the circulation in the exposed spinal cord segment was examined using both procedures, the videomicroscopy as well as the r.S.C.B.F. measurement (by intraarterial-5th radicular injection of 2.5 mic133 Xe). In group B (10 rabbits) after the performance of L1 vertebra mid-laminectomy, a teflon catheter was introduced through T11-T12 (thoracic) intervertebral foramina and 0.5 ml of metrizamide sodium was injected through the balloon producing, thus, a 36 +/- 1% stenosis in the diameter of the corresponding spinal canal level. Using the procedures described above as well as light microscopy it was shown that, during the period of the 4 hours the experiment lasted, the circulatory disturbances of spinal cord were still reversible. On the contrary, in group C (14 rabbits) where 0.8 ml of metriz amide sodium was injected through the balloon catheter producing, thus, a 52 +/- 1% stenosis in the corresponding spinal canal level, the spinal cord disturbances proved irreversible after the 4-hour period of the experiment's duration.
我们的研究在34只兔子身上进行，这些兔子被分为三组（A、B、C）。A组（10只动物），对第一腰椎（L1）进行椎板切除术，并使用视频显微镜以及r.S.C.B.F.测量（通过动脉内-第五神经根注射2.5微升133氙）两种方法检查暴露脊髓节段的血液循环。B组（10只兔子）在进行L1椎板切除术后，通过T11-T12（胸段）椎间孔插入一根聚四氟乙烯导管，并通过球囊注射0.5毫升甲泛葡胺钠，从而在相应脊髓节段水平产生36±1%的管径狭窄。使用上述方法以及光学显微镜显示，在实验持续的4小时内，脊髓的循环障碍仍然是可逆的。相反，在C组（14只兔子）中，通过球囊导管注射0.8毫升甲泛葡胺钠，从而在相应脊髓节段水平产生52±1%的狭窄，在实验持续4小时后，脊髓障碍被证明是不可逆的。
