College of Kinesiology, Shenyang Sport University, Shenyang, China.
Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
Cell Prolif. 2022 Oct;55(10):e13294. doi: 10.1111/cpr.13294. Epub 2022 Jun 23.
Musculoskeletal disorder (MSD) are a class of inflammatory and degener-ative diseases, but the precise molecular mechanisms are still poorly understood. Noncoding RNA (ncRNA) N6-methyladenosine (m6A) modification plays an essential role in the pathophysiological process of MSD. This review summarized the interaction between m6A RNA methylation and ncRNAs in the molecular regulatory mechanism of MSD. It provides a new perspective for the pathophysiological mechanism and ncRNA m6A targeted therapy of MSD.
A comprehensive search of databases was conducted with musculoskeletal disorders, noncoding RNA, N6-methyladenosine, intervertebral disc degeneration, osteoporosis, osteosarcoma, osteoarthritis, skeletal muscle, bone, and cartilage as the key-words. Then, summarized all the relevant articles.
Intervertebral disc degeneration (IDD), osteoporosis (OP), osteosarcoma (OS), and osteoarthritis (OA) are common MSDs that affect muscle, bone, cartilage, and joint, leading to limited movement, pain, and disability. However, the precise pathogenesis remains unclear, and no effective treatment and drug is available at present. Numerous studies confirmed that the mutual regulation between m6A and ncRNAs (i.e., microRNAs, long ncRNAs, and circular RNAs) was found in MSD, m6A modification can regulate ncRNAs, and ncRNAs can also target m6A regulators. ncRNA m6A modification plays an essential role in the pathophysiological process of MSDs by regulating the homeostasis of skeletal muscle, bone, and cartilage.
m6A interacts with ncRNAs to regulate multiple biological processes and plays important roles in IDD, OP, OS, and OA. These studies provide new insights into the pathophysiological mechanism of MSD and targeting m6A-modified ncRNAs may be a promising therapy approach.
肌肉骨骼疾病（MSD）是一类炎症和退行性疾病，但确切的分子机制仍知之甚少。非编码 RNA（ncRNA）N6-甲基腺苷（m6A）修饰在 MSD 的病理生理过程中起着至关重要的作用。本综述总结了 m6A RNA 甲基化与 ncRNA 之间的相互作用在 MSD 的分子调控机制中的作用。为 MSD 的病理生理机制和 ncRNA m6A 靶向治疗提供了新的视角。
以肌肉骨骼疾病、非编码 RNA、N6-甲基腺苷、椎间盘退行性变、骨质疏松症、骨肉瘤、骨关节炎、骨骼肌、骨和软骨为关键词，对数据库进行全面检索。然后，总结了所有相关文章。
椎间盘退行性变（IDD）、骨质疏松症（OP）、骨肉瘤（OS）和骨关节炎（OA）是常见的 MSD，影响肌肉、骨骼、软骨和关节，导致运动受限、疼痛和残疾。然而，确切的发病机制尚不清楚，目前尚无有效的治疗和药物。大量研究证实，在 MSD 中发现了 m6A 与 ncRNAs（即 microRNAs、长 ncRNAs 和环状 RNA）之间的相互调节，m6A 修饰可以调节 ncRNAs，ncRNAs 也可以靶向 m6A 调节因子。ncRNA m6A 修饰通过调节骨骼肌、骨骼和软骨的内稳态在 MSD 的病理生理过程中起着至关重要的作用。
m6A 与 ncRNAs 相互作用调节多种生物学过程，在 IDD、OP、OS 和 OA 中发挥重要作用。这些研究为 MSD 的病理生理机制提供了新的见解，靶向 m6A 修饰的 ncRNAs 可能是一种有前途的治疗方法。
