Samadian Esmaeil, Aghcheli Bahman, Gharaei Roghaye, Tabarraei Alijan
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Infection Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Int J Reprod Biomed. 2023 Feb 8;21(1):1-16. doi: 10.18502/ijrm.v21i1.12661. eCollection 2023 Jan.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the leading cause of the new deadly pneumonia named coronavirus disease 2019 (COVID-19) pandemic. This pathogen has different co-receptors on various tissues, resulting in vast pathophysiological circumstances. Here, we present a comprehensive narrative review focusing on the impact of SARS-CoV2 on human reproduction. Evidence-based literature revealed inconsistent results for this virus in the reproductive organs of patients with COVID-19, even in the critical phase. Conversely, numerous satisfactory data represented those different reproductive activities, from gametogenesis to pregnancy, can be targeted by SARS-CoV2. The severity of COVID-19 depends on the differential expression of the host cellular components required to enter SARS-CoV2. The cytokine storm and oxidative stress coming out during COVID-19 are associated with complications in reproductive endocrinopathies. Men are naturally more susceptible to COVID-19, especially accompanied by orchitis and varicocele. Synergistically the interaction of SARS-CoV2 and female reproductive failures (polycystic ovary syndrome and endometriosis) increases the susceptibility to COVID-19. Thus, pharmaceutical interventions that ameliorate the complications in individuals with reproductive disorders can be helpful to achieve good outcomes in assisted reproductive techniques. Soon, an increase in the infertility rate will likely be an overall impact of SARS-CoV2 in patients who recovered from COVID-19.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是新型致命肺炎——2019冠状病毒病（COVID-19）大流行的主要病因。这种病原体在不同组织上有不同的共受体，导致了广泛的病理生理情况。在此，我们进行一项全面的叙述性综述，重点关注SARS-CoV-2对人类生殖的影响。循证文献显示，即使在关键阶段，该病毒在COVID-19患者生殖器官中的结果也不一致。相反，大量令人满意的数据表明，从配子发生到妊娠的不同生殖活动都可能成为SARS-CoV-2的攻击目标。COVID-19的严重程度取决于宿主细胞成分进入SARS-CoV-2所需的差异表达。COVID-19期间出现的细胞因子风暴和氧化应激与生殖内分泌疾病的并发症有关。男性天生更容易感染COVID-19，尤其是伴有睾丸炎和精索静脉曲张时。协同作用下，SARS-CoV-2与女性生殖功能衰竭（多囊卵巢综合征和子宫内膜异位症）的相互作用会增加对COVID-19的易感性。因此，改善生殖系统疾病患者并发症的药物干预措施可能有助于辅助生殖技术取得良好效果。很快，不孕率上升可能会成为SARS-CoV-2对从COVID-19中康复患者的总体影响。
