Mackinnon L T, Chick T W, van As A, Tomasi T B
Department of Cell Biology, University of New Mexico School of Medicine, Albuquerque.
Adv Exp Med Biol. 1987;216A:869-76. doi: 10.1007/978-1-4684-5344-7_102.
Secretory immunity. 1. Intense endurance exercise suppresses salivary immunoglobulins. The exercise-induced decrease is specific for the secretory antibodies IgA and IgM. 2. The suppression of secretory Ig is transitory, lasting at least one hour, and returning to pre-exercise levels by 24 hours after a single bout of severe exercise. These results suggest that anecdotal statements by athletes and their coaches of an increased susceptibility to upper respiratory infection after severe exercise could be related to changes in secretory immunity. Natural immunity. 1. Natural killer activity of PBL is suppressed one hour after intense endurance exercise. This effect is transitory, since activity returns to pre-exercise levels by 24 hours after a single bout of exercise. 2. The decrease in NK lytic activity is due to a decrease in the percentage of NK cells (Leu-11a+ cells). When NK cell activity is expressed on a per cell basis, it appears that activity is enhanced after exercise.
分泌性免疫。1. 高强度耐力运动可抑制唾液免疫球蛋白。运动引起的下降对分泌性抗体IgA和IgM具有特异性。2. 分泌性Ig的抑制是暂时的，持续至少1小时，并在单次剧烈运动后24小时恢复到运动前水平。这些结果表明，运动员及其教练关于剧烈运动后上呼吸道感染易感性增加的传闻可能与分泌性免疫的变化有关。自然免疫。1. 高强度耐力运动1小时后，外周血淋巴细胞（PBL）的自然杀伤活性受到抑制。这种效应是暂时的，因为在单次运动后24小时活性恢复到运动前水平。2. NK细胞溶解活性的降低是由于NK细胞（Leu-11a+细胞）百分比的下降。当以每个细胞为基础表达NK细胞活性时，运动后活性似乎增强。
