癌症免疫学的新型小鼠模型
Novel Mouse Models for Cancer Immunology.
作者信息
Connolly Kelli A, Fitzgerald Brittany, Damo Martina, Joshi Nikhil S
机构信息
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA.
出版信息
Annu Rev Cancer Biol. 2022 Apr;6(1):269-291. doi: 10.1146/annurev-cancerbio-070620-105523. Epub 2022 Jan 18.
Abstract
Mouse models for the study of cancer immunology provide excellent systems in which to test biological mechanisms of the immune response against cancer. Historically, these models have been designed to have different strengths based on the current major research questions at the time. As such, many mouse models of immunology used today were not originally developed to study questions currently plaguing the relatively new field of cancer immunology, but instead have been adapted for such purposes. In this review, we discuss various mouse model of cancer immunology in a historical context as a means to provide a fuller perspective of each model's strengths. From this outlook, we discuss the current state of the art and strategies for tackling future modeling challenges.
摘要
用于癌症免疫学研究的小鼠模型为测试针对癌症的免疫反应的生物学机制提供了出色的系统。从历史上看，这些模型是根据当时的主要研究问题设计的，各有不同优势。因此，如今使用的许多免疫学小鼠模型最初并非为研究当前困扰相对较新的癌症免疫学领域的问题而开发，而是经过了适应性改造以用于此类目的。在本综述中，我们在历史背景下讨论各种癌症免疫学小鼠模型，以便更全面地了解每种模型的优势。从这个角度出发，我们探讨了当前的技术水平以及应对未来建模挑战的策略。
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