Reddy G K, Dhar S C, Singh G B
Department of Biochemistry, Central Leather Research Institute, Madras, India.
Agents Actions. 1987 Oct;22(1-2):99-105. doi: 10.1007/BF01968824.
The therapeutic effect of boswellic acids and salai guggal in adjuvant induced arthritic rats in relation to urinary excretion of connective tissue metabolites viz. hydroxyproline, hexosamine and uronic acid was thoroughly investigated. Compared to controls, the arthritic animals showed an increase in the excretion of these metabolites in urine. The elevated levels of urinary hydroxyproline (free, total, nondialysable and dialysable), hexosamine and uronic acid in the arthritic animals were found to be slightly decreased in the acute phase and significantly decreased in the chronic phase of the disease following the administration of boswellic acids or salai guggal. The results of the investigation indicated that both these anti-inflammatory drugs could offer a partial protective action against changes induced by adjuvant induced arthritis.
对乳香酸和红没药在佐剂诱导的关节炎大鼠中的治疗效果与结缔组织代谢物（即羟脯氨酸、氨基己糖和糖醛酸）的尿排泄之间的关系进行了全面研究。与对照组相比，患关节炎的动物尿液中这些代谢物的排泄量增加。发现患关节炎动物尿液中羟脯氨酸（游离、总、非透析和透析）、氨基己糖和糖醛酸的升高水平在疾病急性期略有下降，在慢性期经乳香酸或红没药给药后显著下降。研究结果表明，这两种抗炎药均可对佐剂诱导的关节炎引起的变化提供部分保护作用。
