Flynn M Seth, Robinson Camille, Patel Surya, Liu Beiyu, Green Cynthia, Pavlis Michelle
School of Medicine, Duke University, Durham, North Carolina, USA.
Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
JID Innov. 2022 Nov 26;3(2):100173. doi: 10.1016/j.xjidi.2022.100173. eCollection 2023 Mar.
Patients with Parkinson disease (PD) are at high risk for developing melanoma, although current literature lacks details on the associated clinicopathologic characteristics. Our retrospective case-control study aimed to guide skin cancer surveillance recommendations for patients with PD, focusing on tumor sites. Our study included 70 adults with concurrent diagnoses of PD and melanoma from January 1, 2007 to January 1, 2020 at Duke University and 102 age-, sex-, and race-matched controls. The head/neck region accounted for 39.5% of invasive melanomas in the case group compared with 25.3% in the control group as well as 48.7% of noninvasive melanomas in the case group compared with 39.1% in the control group. Of note, 50% of metastatic melanomas in patients with PD originated on the head and neck (n = 3). Logistic regression showed 2.09 times higher odds of having a head/neck melanoma in our case group compared with that in the control group (OR = 2.09, 95% confidence interval = 1.13‒3.86; = 0.020). Our study is limited by small sample size, and our case cohort lacked diversity regarding race, ethnicity, sex, and geography. Validation of the reported trends could provide more robust guidance for melanoma surveillance in patients with PD.
帕金森病（PD）患者患黑色素瘤的风险很高，尽管目前的文献缺乏相关临床病理特征的详细信息。我们的回顾性病例对照研究旨在为PD患者的皮肤癌监测建议提供指导，重点关注肿瘤部位。我们的研究纳入了2007年1月1日至2020年1月1日在杜克大学同时诊断为PD和黑色素瘤的70名成年人以及102名年龄、性别和种族匹配的对照。病例组中头颈部区域占侵袭性黑色素瘤的39.5%，而对照组为25.3%；病例组中非侵袭性黑色素瘤占48.7%，而对照组为39.1%。值得注意的是，PD患者中50%的转移性黑色素瘤起源于头颈部（n = 3）。逻辑回归显示，与对照组相比，我们病例组发生头颈部黑色素瘤的几率高2.09倍（OR = 2.09，95%置信区间 = 1.13‒3.86；P = 0.020）。我们的研究受样本量小的限制，且病例队列在种族、民族、性别和地域方面缺乏多样性。对所报告趋势的验证可为PD患者的黑色素瘤监测提供更有力的指导。
