College of Chemical Engineering, Institute of Pharmaceutical Engineering Technology and Application, Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, Sichuan University of Science & Engineering, Zigong 643000 Sichuan, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Nat Prod Res. 2024 Jul;38(14):2498-2504. doi: 10.1080/14786419.2023.2185889. Epub 2023 Mar 6.
Two new prenylxanthone derivatives, asperidulins A () and B (), along with a known emodin analogue () were isolated from an apple-derived fungus KIB-HACM-01. Their structures were elucidated by interpretation of HRMS, NMR, and comparisons of specific optical rotation. Asperidulin B () exhibited a moderate cytotoxicity against A549 and BEAS-2B with an IC values of 13.62 ± 0.41 and 11.27 ± 0.52 μM, and methyl-averantin () showed moderate cytotoxicities against all six tested cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, SW480, BEAS-2B) with IC values ranging from 8.93 ± 0.56 to 35.27 ± 0.25 μM.
从苹果来源的真菌 KIB-HACM-01 中分离得到了两个新的prenylxanthone 衍生物，asperidulins A () 和 B ()，以及一个已知的大黄素类似物 ()。通过 HRMS、NMR 的解析和比旋光度的比较，确定了它们的结构。Asperidulin B () 对 A549 和 BEAS-2B 的细胞表现出中等的细胞毒性，IC 值分别为 13.62±0.41 和 11.27±0.52 μM，甲基averantin () 对所有六种测试的细胞系（HL-60、A549、SMMC-7721、MDA-MB-231、SW480、BEAS-2B）均表现出中等的细胞毒性，IC 值范围为 8.93±0.56 至 35.27±0.25 μM。
