从红树林相关真菌 HDN1009 中分离得到的细胞毒性四羟基蒽酮二聚体。
Cytotoxic Tetrahydroxanthone Dimers from the Mangrove-Associated Fungus HDN1009.
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China.
出版信息
Mar Drugs. 2018 Sep 14;16(9):335. doi: 10.3390/md16090335.
Three new tetrahydroxanthone dimers, 5--asperdichrome (), versixanthones N (), and O (), were isolated from the mangrove-derived fungus HDN1009. Their structures, including the absolute configurations, were elucidated by NMR, HRMS, and circular dichroism (CD) experiments. Among them, compound was the second example of tetrahydroxanthone dimers, which dimerized by a rare diaryl ether linkage and showed promising antibacterial activities against , , , and , with MIC values ranging from 100 μM to 200 μM; whilst compounds and exhibited extensive cytotoxicities against five cancer cell lines (HL-60, K562, H1975, MGC803, and HO-8910), with IC values ranging from 1.7 μM to 16.1 μM.
从红树林来源的真菌 HDN1009 中分离得到三个新的四羟基蒽酮二聚体：5--asperdichrome ()、versixanthones N () 和 O ()。通过 NMR、HRMS 和圆二色性 (CD) 实验阐明了它们的结构，包括绝对构型。其中，化合物 是第二个四羟基蒽酮二聚体的例子，它通过罕见的二芳基醚键二聚化，并表现出对 、 、 、 和 的有希望的抗菌活性，MIC 值范围为 100 μM 至 200 μM；而化合物 和 对五种癌细胞系（HL-60、K562、H1975、MGC803 和 HO-8910）表现出广泛的细胞毒性，IC 值范围为 1.7 μM 至 16.1 μM。
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