AgroBioSciences Program, College for Sustainable Agriculture and Environmental Science, Mohammed VI Polytechnic University, Ben Guerir, Morocco.
African Sustainable Agriculture Research Institute (ASARI), College for Sustainable Agriculture and Environmental Science, Mohammed VI Polytechnic University, Laayoune, Morocco.
Crit Rev Food Sci Nutr. 2024 Jul;64(21):7343-7362. doi: 10.1080/10408398.2023.2184766. Epub 2023 Mar 6.
Sesquiterpenoids constitute the largest subgroup of terpenoids that have numerous applications in pharmaceutical, flavor, and fragrance industries as well as biofuels. Bergamotenes, a type of bicyclic sesquiterpenes, are found in plants, insects, and fungi with α-trans-bergamotene as the most abundant compound. Bergamotenes and their related structures (Bergamotane sesquiterpenoids) have been shown to possess diverse biological activities such as antioxidant, anti-inflammatory, immunosuppressive, cytotoxic, antimicrobial, antidiabetic, and insecticidal effects. However, studies on their biotechnological potential are still limited. This review compiles the characteristics of bergamotenes and their related structures in terms of occurrence, biosynthesis pathways, and biological activities. It further discusses their functionalities and potential applications in pharmaceutical, nutraceuticals, cosmeceuticals, and pest management sectors. This review also opens novel perspectives in identifying and harnessing bergamotenes for pharmaceutical and agricultural purposes.
倍半萜类化合物是萜类化合物中最大的亚组，它们在制药、香料和香精行业以及生物燃料等领域有多种应用。双环倍半萜类化合物中的佛手柑烯存在于植物、昆虫和真菌中，其中最丰富的化合物是α-反式-佛手柑烯。佛手柑烯及其相关结构（佛手烷倍半萜类化合物）具有多种生物活性，如抗氧化、抗炎、免疫抑制、细胞毒性、抗菌、抗糖尿病和杀虫作用。然而，关于它们的生物技术潜力的研究仍然有限。本文综述了佛手柑烯及其相关结构在发生、生物合成途径和生物活性方面的特征。进一步讨论了它们在制药、营养保健品、化妆品和害虫管理领域的功能和潜在应用。本文还为识别和利用佛手柑烯在制药和农业方面开辟了新的视角。
