Guvenc O, Engin M
Department of Cardiovascular Surgery, Medical Faculty of Uludag University, Bursa, Turkey.
Eur Rev Med Pharmacol Sci. 2023 Feb;27(4):1534-1539. doi: 10.26355/eurrev_202302_31396.
Acute Type A aortic dissection (ATAAD) is an emergency cardiovascular condition. In this current study, we aimed to investigate the prognostic importance of preoperative neutrophil-lymphocyte platelet ratio (NLPR) value in predicting in-hospital mortality, after surgical treatment of ATAAD.
Consecutive patients who underwent an emergency operation as a result of ATAAD between August 2012 and August 2021 in our hospital, were retrospectively included in this study. Patients who survived the operation and were released were recorded as Group 1 and those who died in the hospital, as Group 2.
Mortality (in-hospital) occurred in 44 (22.5%) patients (Group 2). The median age of the 151 patients included in Group 1 and 44 patients in Group 2 were 55 (37 to 81) and 59 (33 to 72) years, respectively (p = 0.191). In multivariate analysis Model 1, malperfusion (OR: 3.764, 95% CI: 2.140-4.152, p < 0.001), total perfusion time (OR: 1.156, 95% CI: 1.040-1.469, p = 0.012), low platelet counts (OR: 0.894, 95% CI: 0.685-0.954, p = 0.035) and NLR (OR: 1.944, 95% CI: 1.230-2.390, p < 0.001) were determined as independent predictors for mortality. In Model 2, malperfusion (OR: 3.391, 95% CI: 2.426-3.965, p < 0.001) and NLPR (OR: 2.371, 95% CI: 1.892-3.519, p < 0.001) were determined as independent predictors for mortality.
According to our study, the NLPR value obtained preoperatively can be used to predict the risk of in-hospital mortality, after ATAAD surgery.
急性A型主动脉夹层（ATAAD）是一种紧急心血管疾病。在本研究中，我们旨在探讨术前中性粒细胞-淋巴细胞-血小板比值（NLPR）值在预测ATAAD手术治疗后院内死亡率方面的预后重要性。
回顾性纳入2012年8月至2021年8月期间在我院因ATAAD接受急诊手术的连续患者。手术存活并出院的患者记录为第1组，在医院死亡的患者记录为第2组。
44例（22.5%）患者发生院内死亡（第2组）。第1组纳入的151例患者和第2组的44例患者的中位年龄分别为55岁（37至81岁）和59岁（33至72岁）（p = 0.191）。在多变量分析模型1中，灌注不良（OR：3.764，95%CI：2.140 - 4.152，p < 0.001）、总灌注时间（OR：1.156，95%CI：1.040 - 1.469，p = 0.012）、低血小板计数（OR：0.894，95%CI：0.685 - 0.954，p = 0.035）和中性粒细胞与淋巴细胞比值（NLR）（OR：1.944，95%CI：1.230 - 2.390，p < 0.001）被确定为死亡的独立预测因素。在模型2中，灌注不良（OR：3.391，95%CI：2.426 - 3.965，p < 0.001）和NLPR（OR：2.371，95%CI：1.892 - 3.519，p < 0.001）被确定为死亡的独立预测因素。
根据我们的研究，术前获得的NLPR值可用于预测ATAAD手术后的院内死亡风险。
