用于治疗氧化应激和炎症的可注射且含表没食子儿茶素没食子酸酯的组织黏附性透明质酸水凝胶储库
Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation.
作者信息
He Zhichao, Luo Huitong, Wang Zetao, Chen Dafu, Feng Qi, Cao Xiaodong
机构信息
Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), South China University of Technology, Guangzhou 510006, PR China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, PR China.
Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), South China University of Technology, Guangzhou 510006, PR China.
出版信息
Carbohydr Polym. 2023 Jan 1;299:120180. doi: 10.1016/j.carbpol.2022.120180. Epub 2022 Oct 1.
Oxidative stress and inflammation are common pathological mechanisms for the progression of tissue degeneration. Epigallocatechin-3-gallate (EGCG) features antioxidant and anti-inflammatory properties, which is a promising drug for the treatment of tissue degeneration. Herein, we utilize the phenylborate ester reaction of EGCG and phenylboronic acid (PBA) to fabricate an injectable and tissue adhesive EGCG-laden hydrogel depot (EGCG HYPOT), which can achieve anti-inflammatory and antioxidative effects via smart delivery of EGCG. Specifically, the phenylborate ester bonds, formed by EGCG and PBA-modified methacrylated hyaluronic acid (HAMA-PBA), endow EGCG HYPOT injectability, shape adaptation and efficient load of EGCG. After photo-crosslinking, EGCG HYPOT exhibits good mechanical properties, tissue adhesion and sustained acid-responsive release of EGCG. EGCG HYPOT can scavenge oxygen and nitrogen free radicals. Meanwhile, EGCG HYPOT can scavenge intracellular reactive oxygen species (ROS) and suppress the expression of pro-inflammatory factors. EGCG HYPOT may provide a new idea for alleviation of inflammatory disturbance.
氧化应激和炎症是组织退化进展的常见病理机制。表没食子儿茶素没食子酸酯（EGCG）具有抗氧化和抗炎特性，是一种有前景的治疗组织退化的药物。在此，我们利用EGCG与苯硼酸（PBA）的硼酸酯反应制备了一种可注射且具有组织粘附性的载EGCG水凝胶储库（EGCG HYPOT），其可通过EGCG的智能递送实现抗炎和抗氧化作用。具体而言，由EGCG与PBA修饰的甲基丙烯酸化透明质酸（HAMA-PBA）形成的硼酸酯键赋予了EGCG HYPOT可注射性、形状适应性和EGCG的高效负载。光交联后，EGCG HYPOT表现出良好的力学性能、组织粘附性以及EGCG的持续酸响应释放。EGCG HYPOT可以清除氧自由基和氮自由基。同时，EGCG HYPOT可以清除细胞内活性氧（ROS）并抑制促炎因子的表达。EGCG HYPOT可能为减轻炎症干扰提供新思路。
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