Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, South Korea.
Department of Food Science and Technology, Chung-Ang University, Anseong, South Korea.
Phytother Res. 2023 Jul;37(7):3069-3082. doi: 10.1002/ptr.7801. Epub 2023 Mar 6.
This study was conducted to investigate the effect of Gynostemma pentaphyllum extract containing gypenoside L (GPE) on improving the cognitive aspects of fatigue and performance of the motor system. One hundred healthy Korean adults aged 19-60 years were randomized to the treatment (GPE for 12 weeks) and control groups, and efficacy and safety-related parameters were compared between the two groups. Maximal oxygen consumption (VO max) and O pulse were significantly higher in the treatment group than in the control group (p = 0.007 and p = 0.047, respectively). After 12 weeks, the treatment group showed significant changes such as decreases in the levels of free fatty acids (p = 0.042). In addition, there were significant differences in the rating of perceived exertion (RPE) (p < 0.05) and value of temporal fatigue between the treatment and control groups on the multidimensional fatigue scale (p < 0.05). Moreover, the level of endothelial nitric oxide synthase (eNOS) in the blood was significantly higher in the treatment group than in the control group (p = 0.047). In summary, oral administration of GPE has a positive effect on resistance to exercise-induced physical and mental fatigue.
本研究旨在探讨含有绞股蓝皂苷（Gypenoside L，GPE）的绞股蓝提取物对改善疲劳和运动系统性能的认知方面的影响。将 100 名年龄在 19-60 岁的健康韩国成年人随机分为治疗（GPE 治疗 12 周）和对照组，并比较两组之间的疗效和安全性相关参数。治疗组的最大摄氧量（VO max）和 O 脉冲明显高于对照组（p = 0.007 和 p = 0.047）。12 周后，治疗组游离脂肪酸水平显著下降（p = 0.042）。此外，多维疲劳量表（Multidimensional Fatigue Scale）上的感觉用力评分（Rating of Perceived Exertion，RPE）（p < 0.05）和时间疲劳值（Temporal Fatigue）有显著差异（p < 0.05）。此外，治疗组的血液内皮型一氧化氮合酶（endothelial nitric oxide synthase，eNOS）水平明显高于对照组（p = 0.047）。总之，口服 GPE 对抵抗运动引起的身心疲劳有积极作用。
