Department of Molecular Medicine & Surgery, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Horm Metab Res. 2010 May;42(5):353-7. doi: 10.1055/s-0030-1248298. Epub 2010 Mar 8.
The aim of the study was to investigate the antidiabetic effect of the traditional Vietnamese herb Gynostemma pentaphyllum in 24 drug-naïve type 2 diabetic patients. All patients were randomized to authenticated Gynostemma pentaphyllum tea or placebo tea, 6 g daily, during twelve weeks and received information regarding diet and exercise. Fasting plasma glucose, insulin levels, and glycosylated hemoglobin (HbA(1C)) were measured before, during, and after the treatment. Oral glucose tolerance tests were performed every four weeks. After 12-week treatment, fasting plasma glucose levels totally decreased to an extent of 3.0+/-1.8 mmol/l in the Gynostemma pentaphyllum tea group as compared to a decrease of 0.6+/-2.2 mmol/l in the control group (p<0.01). HbA(1C) levels after 12 weeks decreased approximately 2% units in the Gynostemma pentaphyllum group compared to 0.2% unit in the controls (p<0.001). Change in Homeostasis Model Assessment-Insulin Resistance between baseline and twelfth week indicated that insulin resistance decreased significantly in the Gynostemma pentaphyllum group (-2.1+/-3.0) compared with that (+1.1+/-3.3) in the control group (p<0.05). There were no hypoglycemias, or adverse effects regarding kidney and liver parameters or gastrointestinal function. In addition, lipid profiles, glucagon, cortisol levels, body measurements, and blood pressure were not different between the groups. This study shows a prompt improvement of glycemia and insulin sensitivity, and thereby provides a basis for a novel, effective, and safe approach, using Gynostemma pentaphyllum tea, to treat type 2 diabetic patients.
本研究旨在探讨传统越南草药绞股蓝在 24 例未经药物治疗的 2 型糖尿病患者中的抗糖尿病作用。所有患者均随机分为经鉴定的绞股蓝茶或安慰剂茶，每天 6 克，持续 12 周，并接受关于饮食和运动的信息。在治疗前、治疗期间和治疗后测量空腹血糖、胰岛素水平和糖化血红蛋白（HbA（1C））。每四周进行一次口服葡萄糖耐量试验。经过 12 周的治疗，与对照组相比，绞股蓝茶组的空腹血糖水平总共降低了 3.0+/-1.8 mmol/l（p<0.01）。与对照组相比，HbA（1C）水平在 12 周后降低了约 2%单位（p<0.001）。与基线相比，第 12 周时稳态模型评估-胰岛素抵抗的变化表明，胰岛素抵抗在绞股蓝组中显著降低（-2.1+/-3.0），而在对照组中仅增加（+1.1+/-3.3）（p<0.05）。没有低血糖，也没有关于肾脏和肝脏参数或胃肠道功能的不良反应。此外，两组之间的血脂谱、胰高血糖素、皮质醇水平、身体测量和血压没有差异。本研究表明，绞股蓝茶能迅速改善血糖和胰岛素敏感性，为使用绞股蓝茶治疗 2 型糖尿病患者提供了一种新的、有效和安全的方法。
