Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.
Nutrients. 2023 Nov 8;15(22):4721. doi: 10.3390/nu15224721.
This research aimed to determine the effects of Gynostemma pentaphyllum () on exercise performance, AMP-activated protein kinase (AMPK), and mitochondrial signaling in human muscle. This randomized double-blind placebo control crossover study provided placebo or 450 mg of dried leaf extract equivalent to 2.25 g of dry leaf per day for four weeks to 16 healthy untrained young males, separated by four weeks wash-out. Following 4-week supplementation with participants had significantly lower leptin and blood glucose levels and improved time trial performance over 20 km, which corresponded with a higher muscle oxygen flux compared to placebo. Muscle AMPK Thr172 phosphorylation significantly increased after 60 min exercise following supplementation. AMPK Thr172 phosphorylation levels relative to total AMPK increased earlier following exercise with compared to placebo. Total ACC-α was lower following supplementation compared to placebo. While further research is warranted, supplementation improved exercise performance in healthy untrained males, which corresponded with improved mitochondrial respiration, altered AMPK and ACC, and decreased plasma leptin and glucose levels.
本研究旨在确定绞股蓝（）对人体肌肉运动表现、 AMP 激活的蛋白激酶（AMPK）和线粒体信号的影响。这项随机、双盲、安慰剂对照交叉研究向 16 名健康、未经训练的年轻男性提供安慰剂或 450 毫克干叶提取物，相当于每天 2.25 克干叶，持续四周，中间间隔四周洗脱期。经过四周的补充后，参与者的瘦素和血糖水平显著降低，20 公里计时赛的表现得到改善，与安慰剂相比，肌肉耗氧量增加。补充后，运动 60 分钟后肌肉 AMPK Thr172 磷酸化显著增加。与安慰剂相比，运动后 AMPK Thr172 磷酸化水平相对于总 AMPK 更早增加。与安慰剂相比，补充后总 ACC-α 降低。虽然还需要进一步的研究，但补充绞股蓝可提高健康、未经训练男性的运动表现，这与改善线粒体呼吸、改变 AMPK 和 ACC 以及降低血浆瘦素和葡萄糖水平有关。
