Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University, No 1838 Guangzhou Northern Road, Guangzhou, 510515, China.
BMC Womens Health. 2024 Jun 1;24(1):315. doi: 10.1186/s12905-024-03164-2.
Sleep health and obesity may affect the risk of female infertility. However, few studies focused on the interaction of obesity and sleep health on the female infertility risk. This study aimed to evaluate the combined impact of trouble sleeping / sleep duration and overweight/obesity/ abdominal obesity on the risk of female infertility.
The data for this cross-sectional study was obtained from National Health and Nutritional Examination Survey, which provided information on trouble sleeping, sleep duration, overweight/obesity, abdominal obesity, and confounding factors. Adopted weighted univariate and multivariate logistic regression models to explore the relationship between trouble sleeping, sleep duration, overweight/obesity, abdominal obesity, and the risk of infertility, respectively, and the combined effect of trouble sleeping and overweight/obesity, trouble sleeping and abdominal obesity, sleep duration and overweight/obesity, sleep duration and abdominal obesity, on the female infertility risk.
This study included a total of 1,577 women, and 191 were diagnosed with infertility. Women with infertility had a higher proportion of people with overweight/obesity, abdominal obesity, sleep duration ≤ 7 h and trouble sleeping than those with non-infertility. The result indicated that trouble sleeping [odds ratio (OR) = 2.25, 95% confidence intervals (CI): 1.49-3.39], sleep duration ≤ 7 h (OR = 1.59, 95% CI: 1.03-2.48), and the combined impact of abdominal obesity and trouble sleeping (OR = 2.18, 95% CI: 1.28-3.72), abdominal obesity and sleep duration ≤ 7 h (OR = 2.00, 95% CI: 1.17-3.40), overweight/obesity and trouble sleeping (OR = 2.29, 95% CI: 1.24-4.26), and overweight/obesity and sleep duration ≤ 7 h (OR = 1.88, 95% CI: 1.01-3.49) were associated with increased odds of infertility, respectively.
There was combined effects of trouble sleeping/sleep duration ≤ 7 h and overweight/obesity/ abdominal obesity on increased odds of female infertility.
睡眠健康和肥胖可能会影响女性不孕的风险。然而，很少有研究关注肥胖和睡眠健康对女性不孕风险的相互作用。本研究旨在评估睡眠困难/睡眠时间和超重/肥胖/腹型肥胖对女性不孕风险的综合影响。
这项横断面研究的数据来自国家健康和营养调查，该调查提供了关于睡眠困难、睡眠时间、超重/肥胖、腹型肥胖和混杂因素的信息。采用加权单变量和多变量逻辑回归模型，分别探讨睡眠困难、睡眠时间、超重/肥胖、腹型肥胖与不孕风险之间的关系，以及睡眠困难和超重/肥胖、睡眠困难和腹型肥胖、睡眠时间和超重/肥胖、睡眠时间和腹型肥胖对女性不孕风险的综合影响。
本研究共纳入 1577 名女性，其中 191 人被诊断为不孕。不孕女性中，超重/肥胖、腹型肥胖、睡眠时间≤7 小时和睡眠困难的比例高于非不孕女性。结果表明，睡眠困难[比值比（OR）=2.25，95%置信区间（CI）：1.49-3.39]、睡眠时间≤7 小时（OR=1.59，95%CI：1.03-2.48）以及腹型肥胖和睡眠困难的综合影响（OR=2.18，95%CI：1.28-3.72）、腹型肥胖和睡眠时间≤7 小时（OR=2.00，95%CI：1.17-3.40）、超重/肥胖和睡眠困难（OR=2.29，95%CI：1.24-4.26）以及超重/肥胖和睡眠时间≤7 小时（OR=1.88，95%CI：1.01-3.49）与不孕的几率增加相关。
睡眠困难/睡眠时间≤7 小时和超重/肥胖/腹型肥胖对女性不孕的几率增加有联合作用。
