镍催化芳基和烯基三氟甲磺酸酯与烷基硫醇的交叉偶联反应。
Nickel Catalyzed Cross-Coupling of Aryl and Alkenyl Triflates with Alkyl Thiols.
机构信息
Institute of Organic Chemistry, Faculty of Science, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany.
出版信息
Org Lett. 2023 Mar 17;25(10):1655-1660. doi: 10.1021/acs.orglett.3c00218. Epub 2023 Mar 6.
PMID:36877862
Abstract
We report a nickel catalyzed C-S cross-coupling of aryl and alkenyl triflates with alkyl thiols. A variety of the corresponding thioethers were synthesized using an air-stable nickel precatalyst under mild reaction conditions with short reaction times. A broad substrate scope, including pharmaceutically relevant compounds, could be demonstrated.
摘要
我们报告了镍催化的芳基和烯基三氟甲磺酸酯与烷基硫醇的 C-S 交叉偶联。在温和的反应条件下，使用空气稳定的镍前催化剂和短的反应时间，可以合成各种相应的硫醚。可以证明具有广泛的底物范围，包括药物相关的化合物。
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