Zhao X L, Chan M Y, Kumana C R, Ogle C W
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Am J Chin Med. 1987;15(1-2):59-67. doi: 10.1142/S0192415X87000084.
Plants belonging to the Eupatorium species, E. japonicum Thunb, E. fortunei and E. chinense, were found to contain very low concentrations of pyrrolizidine alkaloid compared with a known hepatotoxic Indian herbal mixture and Crotalaria assamica. High concentrations of pyrrolic metabolite were detected in livers of mice given a single oral dose of extracts of Indian herbal mixture or C. assamica but not in the case of the Eupatorium species. Also, accumulation of pyrrole metabolites was not demonstrated with chronic administration of decoctions prepared from herbs of the Eupatorium species.
与已知具有肝毒性的印度草药混合物及印度猪屎豆相比，泽兰属植物，包括泽兰、佩兰和华泽兰，被发现含有极低浓度的吡咯里西啶生物碱。给小鼠单次口服印度草药混合物或印度猪屎豆提取物后，在其肝脏中检测到高浓度的吡咯代谢物，但泽兰属植物提取物则未出现这种情况。此外，长期服用泽兰属植物制成的汤剂也未显示出吡咯代谢物的蓄积。
