Li Tong-Tong, Li Gang, Hu Rui, Ji Xin, Liu Chang, Shao Yun-Ting
General Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Department of Geriatrics, Hebei General Hospital, Shijiazhuang, 050000, China.
Neurochem Res. 2023 Jul;48(7):2059-2065. doi: 10.1007/s11064-023-03895-y. Epub 2023 Mar 6.
Sulfatides are unique sphingolipids present in the serum and the plasma membrane. Sulfatides exert important functions in a number of systems in the human body, including the nervous, immune, cardiovascular, and coagulation systems.Furthermore, it is closely related to tumor occurrence, development, and metastasis. Peroxisome proliferators-activated receptor α (PPARα) is a class of the nuclear receptor superfamily of transcription factors, which is a potential regulator of sulfatides. This review not only summarizes the current knowledge on the physiological functions of sulfatides in various systems, but also discusses the possible PPARα regulatory mechanisms in sulfatide metabolism and functions. The results of the present analysis provide deep insights and further novel ideas for expanding the research on the physiological function and clinical application of sulfatides.
硫脂是存在于血清和质膜中的独特鞘脂。硫脂在人体的多个系统中发挥重要作用，包括神经、免疫、心血管和凝血系统。此外，它与肿瘤的发生、发展和转移密切相关。过氧化物酶体增殖物激活受体α（PPARα）是一类核受体超家族转录因子，是硫脂的潜在调节因子。本综述不仅总结了目前关于硫脂在各种系统中生理功能的知识，还讨论了PPARα在硫脂代谢和功能中可能的调节机制。本分析结果为拓展硫脂生理功能及临床应用的研究提供了深刻见解和新的思路。
